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Translational Control in p53 Expression: The Role of 5′-Terminal Region of p53 mRNA

Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland
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Int. J. Mol. Sci. 2019, 20(21), 5382; https://doi.org/10.3390/ijms20215382
Received: 19 September 2019 / Revised: 14 October 2019 / Accepted: 27 October 2019 / Published: 29 October 2019
(This article belongs to the Special Issue p53 in Cancer and beyond—40 Years after Its Discovery)
In this review, the latest research concerning the structure and function of the 5′-terminal region of p53 mRNA was discussed. Special attention was focused on defined structural motifs which are present in this region, as well as their conservation and plausible functional role in translation. It is known that the length of the 5′-terminal region and the structural environment of initiation codons can strongly modulate translation initiation. The ability of this region of p53 mRNA to bind protein factors was also described with special emphasis on general principles that govern, such RNA-protein interactions. The structural alterations within the 5′-terminal region of p53 mRNA and proteins that bind to this region have a strong impact on the rate of mRNA scanning and on translation efficiency in in vitro assays, in selected cell lines, and under stress conditions. Thus, the structural features of the 5′-terminal region of p53 mRNA seem to be very important for translation and for translation regulation mechanisms. Finally, we suggested topics that, in our opinion, should be further explored for better understanding of the mechanisms of the p53 gene expression regulation at the translational level. View Full-Text
Keywords: p53 expression; p53 mRNA; 5′ untranslated region; 5′ non-coding region; 5′UTR; transcription; translation initiation; translation regulation p53 expression; p53 mRNA; 5′ untranslated region; 5′ non-coding region; 5′UTR; transcription; translation initiation; translation regulation
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MDPI and ACS Style

Swiatkowska, A.; Dutkiewicz, M.; Zydowicz-Machtel, P.; Szpotkowska, J.; Janecki, D.M.; Ciesiołka, J. Translational Control in p53 Expression: The Role of 5′-Terminal Region of p53 mRNA. Int. J. Mol. Sci. 2019, 20, 5382. https://doi.org/10.3390/ijms20215382

AMA Style

Swiatkowska A, Dutkiewicz M, Zydowicz-Machtel P, Szpotkowska J, Janecki DM, Ciesiołka J. Translational Control in p53 Expression: The Role of 5′-Terminal Region of p53 mRNA. International Journal of Molecular Sciences. 2019; 20(21):5382. https://doi.org/10.3390/ijms20215382

Chicago/Turabian Style

Swiatkowska, Agata; Dutkiewicz, Mariola; Zydowicz-Machtel, Paulina; Szpotkowska, Joanna; Janecki, Damian M.; Ciesiołka, Jerzy. 2019. "Translational Control in p53 Expression: The Role of 5′-Terminal Region of p53 mRNA" Int. J. Mol. Sci. 20, no. 21: 5382. https://doi.org/10.3390/ijms20215382

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