Insights into the Pathophysiology of Infertility in Females with Classical Galactosaemia
Abstract
:1. Introduction
2. Methods
3. Background
3.1. Galactosaemia and Galactose Metabolism
3.2. Primary Ovarian Insufficiency in Female Galactosaemia Patients
3.3. Link to Primordial Germ Cell Signalling
4. Approaches to Treatment
Fertility Preservation
5. New Horizons and Future Prospects for Fertility Treatments in Classical Galactosaemia
6. Conclusion
Author Contributions
Funding
Conflicts of Interest
Abbreviations
Akt | Protein kinase B |
AMH | Anti-Mullerian hormone |
CG | Classical Galactosaemia |
FOX03 | Forkhead box 03 gene |
FSH | Follicle stimulating hormone |
LH | Luteinizing hormone |
Gal | Galactosaemia |
Gal-1-P | Galactose-1-phosphate |
GALT | Galactose-1-phosphate uridylytransferase |
GALE | Galactose epimerase |
GALK | Galactokinase |
GALM | Galactose mutarotase |
MTORC1 | Mammalian target of rapamycin complex 1 |
P13K | Phosphatidylinositol 3-kinase |
POI | Primary Ovarian Insufficiency |
PTEN | Phosphatase and tensin homolog |
UDP-Gal | Uridine diphosphate galactose |
UGP | UDP-glucose pyrophosphorylase |
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Abidin, Z.; Treacy, E.P. Insights into the Pathophysiology of Infertility in Females with Classical Galactosaemia. Int. J. Mol. Sci. 2019, 20, 5236. https://doi.org/10.3390/ijms20205236
Abidin Z, Treacy EP. Insights into the Pathophysiology of Infertility in Females with Classical Galactosaemia. International Journal of Molecular Sciences. 2019; 20(20):5236. https://doi.org/10.3390/ijms20205236
Chicago/Turabian StyleAbidin, Zaza, and Eileen P. Treacy. 2019. "Insights into the Pathophysiology of Infertility in Females with Classical Galactosaemia" International Journal of Molecular Sciences 20, no. 20: 5236. https://doi.org/10.3390/ijms20205236