Tackling Missing Heritability by Use of an Optimum Curve: A Systematic Review and Meta-Analysis
Abstract
:1. Introduction
2. Results
2.1. Search Results
2.2. Primary Data and Synthesis of the Results
2.3. Across Study Bias
2.4. Sensitivity Analysis
3. Discussion
3.1. Relevance
3.2. Strengths and Limitations
3.3. Suggestions for Future Research
4. Methods
4.1. Search Strategy
4.2. Selection Criteria
4.3. Data Extraction
4.4. Statistical Analysis
4.5. Synthesis of Results
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Publication | Origin of Sample | Samples | T: S NT: L | T: L NT: S | Pref. | p |
---|---|---|---|---|---|---|
AMERICA | ||||||
Cook et al., 1997 [16] | United States | 86 trios | 48 | 29 | S | 0.031 |
Persico et al., 2000 (sample b) [17] | United States | 32 trios 5 multiplex | 21 | 20 | – | 0.88 |
Kim et al., 2002 [18] | United States | 115 trios | 43 | 30 | – | 0.13 |
McCauley et al., 2004 [19] | United States | 123 multiplex | 135 | 104 | S | 0.045 |
Devlin et al., 2005 [20] | United States | 103 trios 125 multiplex | 175 | 137 | S | 0.031 |
EUROPE | ||||||
Klauck et al., 1997 [21] | Germany and Austria | 65 trios | 23 | 40 | L | 0.032 |
Persico et al., 2000 (sample a) [17] | Italy | 46 trios 8 duos | 27 | 22 | – | 0.48 |
Tordjman et al., 2001 [22] | France | 42 trios 2 multiplex | 24 | 40 | L | 0.046 |
Coutinho et al., 2004 [23] | Portugal | 182 families | 88 | 79 | – | 0.49 |
Conroy et al., 2004 [24] | Ireland | 84 trios | 55 | 34 | S | 0.026 |
Mulder et al., 2005 [25] | The Netherlands | 111 trios 3 duos 3 multiplex | 54 | 51 | – | 0.77 |
Guerini et al., 2006 [26] | Italy | 34 singleton 3 multiplex | 22 | 22 | – | 1.0 |
ASIA | ||||||
Yirmiya et al., 2001 [27] | Israel | 33 families | 11 | 25 | L | 0.020 |
Guhathakurta et al., 2006 [28] | India | 61 trios 18 duos | 22 | 19 | – | 0.64 |
Koishi et al., 2006 [29] | Japan | 104 trios | 31 | 44 | – | 0.13 |
Cho et al., 2007 [30] | Korea | 126 trios | 45 | 66 | L | 0.046 |
MIXED | ||||||
Maestrini et al., 1999 [31] | America and Europe | 8 singleton 82 multiplex | 72 | 76 | – | 0.74 |
Betancur et al., 2002 [32] | America and Europe | 43 trios 53 multiplex | 71 | 55 | – | 0.15 |
total American | 589 families | S | <0.001 | |||
total European | 588 families | – | 0.81 | |||
total Asian | 342 families | L | 0.007 | |||
total mixed American/European | 186 families | |||||
total overall | 1705 families | – | 0.079 |
Samples | Q | p | I2 | Conclusion |
---|---|---|---|---|
American | 1.68 | 0.79 | 0.00 | homogeneous |
European | 14.27 | 0.027 | 0.58 | heterogeneous |
Asian | 4.23 | 0.24 | 0.29 | homogeneous |
All | 40.39 | 0.001 | 0.58 | heterogeneous |
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Wegener Sleeswijk, A.; Heijungs, R.; Durston, S. Tackling Missing Heritability by Use of an Optimum Curve: A Systematic Review and Meta-Analysis. Int. J. Mol. Sci. 2019, 20, 5104. https://doi.org/10.3390/ijms20205104
Wegener Sleeswijk A, Heijungs R, Durston S. Tackling Missing Heritability by Use of an Optimum Curve: A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences. 2019; 20(20):5104. https://doi.org/10.3390/ijms20205104
Chicago/Turabian StyleWegener Sleeswijk, Anneke, Reinout Heijungs, and Sarah Durston. 2019. "Tackling Missing Heritability by Use of an Optimum Curve: A Systematic Review and Meta-Analysis" International Journal of Molecular Sciences 20, no. 20: 5104. https://doi.org/10.3390/ijms20205104