Next Article in Journal
DockNmine, a Web Portal to Assemble and Analyse Virtual and Experimental Interaction Data
Previous Article in Journal
Evolutionary Analysis of JAZ Proteins in Plants: An Approach in Search of the Ancestral Sequence
Previous Article in Special Issue
Solid Nanocrystals of Rebamipide Promote Recovery from Indomethacin-Induced Gastrointestinal Bleeding
Open AccessArticle

Effects of Encapsulated Cells on the Physical–Mechanical Properties and Microstructure of Gelatin Methacrylate Hydrogels

1
Department of Industrial, Manufacturing, and Systems Engineering, Texas Tech University, Lubbock, TX 79409, USA
2
School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(20), 5061; https://doi.org/10.3390/ijms20205061
Received: 26 September 2019 / Revised: 9 October 2019 / Accepted: 10 October 2019 / Published: 12 October 2019
(This article belongs to the Special Issue Cell-Biomaterial Interaction 2019)
Gelatin methacrylate (GelMA) has been gaining popularity in recent years as a photo-crosslinkable biomaterial widely used in a variety of bioprinting and tissue engineering applications. Several studies have established the effects of process-based and material-based parameters on the physical–mechanical properties and microstructure of GelMA hydrogels. However, the effect of encapsulated cells on the physical–mechanical properties and microstructure of GelMA hydrogels has not been fully understood. In this study, 3T3 fibroblasts were encapsulated at different cell densities within the GelMA hydrogels and incubated over 96 h. The effects of encapsulated cells were investigated in terms of mechanical properties (tensile modulus and strength), physical properties (swelling and degradation), and microstructure (pore size). Cell viability was also evaluated to confirm that most cells were alive during the incubation. It was found that with an increase in cell density, the mechanical properties decreased, while the degradation and the pore size increased. View Full-Text
Keywords: gelatin methacrylate (GelMA); encapsulated cells; physical–mechanical properties; microstructure; tissue engineering gelatin methacrylate (GelMA); encapsulated cells; physical–mechanical properties; microstructure; tissue engineering
Show Figures

Graphical abstract

MDPI and ACS Style

Krishnamoorthy, S.; Noorani, B.; Xu, C. Effects of Encapsulated Cells on the Physical–Mechanical Properties and Microstructure of Gelatin Methacrylate Hydrogels. Int. J. Mol. Sci. 2019, 20, 5061.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop