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The Role of MicroRNAs in Selected Forms of Glomerulonephritis

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Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Powstańców Wlkp 72 Str, 70-111 Szczecin, Poland
2
Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wlkp 72 Str, 70-111 Szczecin, Poland
3
Department of Physiology, Pomeranian Medical University, Powstańców Wlkp 72 Str, 70-111 Szczecin, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(20), 5050; https://doi.org/10.3390/ijms20205050
Received: 18 September 2019 / Revised: 5 October 2019 / Accepted: 9 October 2019 / Published: 11 October 2019
(This article belongs to the Section Molecular Biology)
Glomerulonephritis (GN) represents a collection of kidney diseases characterized by inflammation within the renal glomeruli and small blood vessels. The lesions that occur in other nephron structures mainly result from the harmful effects of proteinuria. In recent years, an emphasis has been placed on gaining a better insight into the pathogenesis and pathophysiology of GN in order to facilitate diagnoses and provide efficient and targeted treatments of the disease. Owing to the advanced molecular and genetic diagnostic techniques available today, researchers have been able to elucidate that most cases of GN are determined by genetic risk factors and are associated with the abnormal functioning of the immune system (the immunologically mediated forms of GN). MicroRNAs (miRNAs) are a group of single-stranded, non-coding molecules, approximately 20 nucleotides in length, that act as regulatory factors in the post-transcriptional processes capable of regulating the expression of multiple genes. In this paper we present the available research aiming to determine effects of miRNAs on the development and progression of GN and discuss the potential role of miRNAs as new diagnostic markers and therapeutic targets. View Full-Text
Keywords: microRNA; chronic kidney disease; IgA nephropathy; lupus nephritis; focal segmental glomerulonephritis; minimal chance disease microRNA; chronic kidney disease; IgA nephropathy; lupus nephritis; focal segmental glomerulonephritis; minimal chance disease
MDPI and ACS Style

Nalewajska, M.; Gurazda, K.; Styczyńska-Kowalska, E.; Marchelek-Myśliwiec, M.; Pawlik, A.; Dziedziejko, V. The Role of MicroRNAs in Selected Forms of Glomerulonephritis. Int. J. Mol. Sci. 2019, 20, 5050.

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