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Review

Polyphenol Health Effects on Cardiovascular and Neurodegenerative Disorders: A Review and Meta-Analysis

1
Dipartimento di Medicina e Chirurgia, Unità di Neuroscienze, Università di Parma, via Volturno 39/F, 43125 Parma, Italy
2
Dipartimento di Scienze Biomediche, Metaboliche e Neuroscienze, Unità di Endocrinologia, Università degli Studi di Modena e Reggio Emilia, via del Pozzo 71, 41124 Modena, Italy
3
Dipartimento di Medicine Specialistiche-Unità di Endocrinologia, Azienda Ospedaliero-Universitaria di Modena, Ospedale Civile di Baggiovara, via Giardini 1355, 41126 Modena, Italy
4
Dipartimento di Scienze degli Alimenti e del Farmaco, Università di Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(2), 351; https://doi.org/10.3390/ijms20020351
Received: 7 December 2018 / Revised: 10 January 2019 / Accepted: 11 January 2019 / Published: 16 January 2019
(This article belongs to the Special Issue Polyphenols: Nutrition, Physiology, Metabolism and Health Benefits)
Several studies have demonstrated that polyphenol-enriched diets may have beneficial effects against the development of degenerative diseases, including atherosclerosis and disorders affecting the central nervous system. This activity has been associated not only with antioxidant and anti-inflammatory properties, but also with additional mechanisms, such as the modulation of lipid metabolism and gut microbiota function. However, long-term studies on humans provided controversial results, making the prediction of polyphenol impact on health uncertain. The aim of this review is to provide an overview and critical analysis of the literature related to the effects of the principal dietary polyphenols on cardiovascular and neurodegenerative disorders. We critically considered and meta-analyzed randomized controlled clinical trials involving subjects taking polyphenol-based supplements. Although some polyphenols might improve specific markers of cardiovascular risk and cognitive status, many inconsistent data are present in literature. Therefore, definitive recommendations for the use of these compounds in the prevention of cardiovascular disease and cognitive decline are currently not applicable. Once pivotal aspects for the definition of polyphenol bioactivity, such as the characterization of pharmacokinetics and safety, are addressed, it will be possible to have a clear picture of the realistic potential of polyphenols for disease prevention. View Full-Text
Keywords: polyphenols; prevention; cardiovascular disease; neurodegenerative disease; cognitive decline; meta-analysis; blood pressure; flow mediated dilation; low density lipoproteins; memory polyphenols; prevention; cardiovascular disease; neurodegenerative disease; cognitive decline; meta-analysis; blood pressure; flow mediated dilation; low density lipoproteins; memory
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MDPI and ACS Style

Potì, F.; Santi, D.; Spaggiari, G.; Zimetti, F.; Zanotti, I. Polyphenol Health Effects on Cardiovascular and Neurodegenerative Disorders: A Review and Meta-Analysis. Int. J. Mol. Sci. 2019, 20, 351. https://doi.org/10.3390/ijms20020351

AMA Style

Potì F, Santi D, Spaggiari G, Zimetti F, Zanotti I. Polyphenol Health Effects on Cardiovascular and Neurodegenerative Disorders: A Review and Meta-Analysis. International Journal of Molecular Sciences. 2019; 20(2):351. https://doi.org/10.3390/ijms20020351

Chicago/Turabian Style

Potì, Francesco, Daniele Santi, Giorgia Spaggiari, Francesca Zimetti, and Ilaria Zanotti. 2019. "Polyphenol Health Effects on Cardiovascular and Neurodegenerative Disorders: A Review and Meta-Analysis" International Journal of Molecular Sciences 20, no. 2: 351. https://doi.org/10.3390/ijms20020351

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