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Int. J. Mol. Sci. 2019, 20(2), 285; https://doi.org/10.3390/ijms20020285

Brain-Derived Neurotrophic Factor Is Required for the Neuroprotective Effect of Mifepristone on Immature Purkinje Cells in Cerebellar Slice Culture

1
Department of Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
2
INSERM UMR 1195 Inserm and Universities Paris-Sud and Paris-Saclay, 80 rue du Général Leclerc, 94276 Kremlin-Bicêtre, France
*
Author to whom correspondence should be addressed.
Received: 26 December 2018 / Revised: 8 January 2019 / Accepted: 10 January 2019 / Published: 12 January 2019
(This article belongs to the Special Issue Brain-Derived Neurotrophic Factor 2018)
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Abstract

Endogenous γ-aminobutyric acid (GABA)-dependent activity induces death of developing Purkinje neurons in mouse organotypic cerebellar cultures and the synthetic steroid mifepristone blocks this effect. Here, using brain-derived neurotrophic factor (BDNF) heterozygous mice, we show that BDNF plays no role in immature Purkinje cell death. However, interestingly, BDNF haploinsufficiency impairs neuronal survival induced by mifepristone and GABAA-receptors antagonist (bicuculline) treatments, indicating that the underlying neuroprotective mechanism requires the neurotrophin full expression. View Full-Text
Keywords: Purkinje cells; mifepristone; BDNF; GABAA receptors; MAP-kinase Purkinje cells; mifepristone; BDNF; GABAA receptors; MAP-kinase
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Rakotomamonjy, J.; Ghoumari, A.M. Brain-Derived Neurotrophic Factor Is Required for the Neuroprotective Effect of Mifepristone on Immature Purkinje Cells in Cerebellar Slice Culture. Int. J. Mol. Sci. 2019, 20, 285.

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