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Article

A Generalized Kinetic Model for Coupling between Stepping and ATP Hydrolysis of Kinesin Molecular Motors

by 1,2,*, 2 and 1
1
School of Materials Science and Energy Engineering, FoShan University, Guangdong 528000, China
2
Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(19), 4911; https://doi.org/10.3390/ijms20194911
Received: 5 August 2019 / Revised: 23 September 2019 / Accepted: 23 September 2019 / Published: 3 October 2019
(This article belongs to the Section Molecular Biophysics)
A general kinetic model is presented for the chemomechanical coupling of dimeric kinesin molecular motors with and without extension of their neck linkers (NLs). A peculiar feature of the model is that the rate constants of ATPase activity of a kinesin head are independent of the strain on its NL, implying that the heads of the wild-type kinesin dimer and the mutant with extension of its NLs have the same force-independent rate constants of the ATPase activity. Based on the model, an analytical theory is presented on the force dependence of the dynamics of kinesin dimers with and without extension of their NLs at saturating ATP. With only a few adjustable parameters, diverse available single molecule data on the dynamics of various kinesin dimers, such as wild-type kinesin-1, kinesin-1 with mutated residues in the NLs, kinesin-1 with extension of the NLs and wild-type kinesin-2, under varying force and ATP concentration, can be reproduced very well. Additionally, we compare the power production among different kinesin dimers, showing that the mutation in the NLs reduces the power production and the extension of the NLs further reduces the power production. View Full-Text
Keywords: molecular motor; kinesin; mechanochemistry; ATPase activity; dynamics; model molecular motor; kinesin; mechanochemistry; ATPase activity; dynamics; model
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MDPI and ACS Style

Xie, P.; Guo, S.-K.; Chen, H. A Generalized Kinetic Model for Coupling between Stepping and ATP Hydrolysis of Kinesin Molecular Motors. Int. J. Mol. Sci. 2019, 20, 4911. https://doi.org/10.3390/ijms20194911

AMA Style

Xie P, Guo S-K, Chen H. A Generalized Kinetic Model for Coupling between Stepping and ATP Hydrolysis of Kinesin Molecular Motors. International Journal of Molecular Sciences. 2019; 20(19):4911. https://doi.org/10.3390/ijms20194911

Chicago/Turabian Style

Xie, Ping, Si-Kao Guo, and Hong Chen. 2019. "A Generalized Kinetic Model for Coupling between Stepping and ATP Hydrolysis of Kinesin Molecular Motors" International Journal of Molecular Sciences 20, no. 19: 4911. https://doi.org/10.3390/ijms20194911

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