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Review

Extracellular Matrix Remodeling of Adipose Tissue in Obesity and Metabolic Diseases

1
Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain
2
Instituto de Investigación Biosanitaria IBS.GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain
3
RG Adipocytes and metabolism, Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Center Munich, 85764 Neuherberg, Munich, Germany
4
Institute of Nutrition and Food Technology "José Mataix", Center of Biomedical Research, University of Granada, Avda. del Conocimiento s/n., 18016 Armilla, Granada, Spain
5
CIBEROBN (CIBER Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, 28029 Madrid, Spain
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(19), 4888; https://doi.org/10.3390/ijms20194888
Received: 3 September 2019 / Revised: 25 September 2019 / Accepted: 29 September 2019 / Published: 2 October 2019
(This article belongs to the Special Issue Molecular Research on Obesity and Metabolic Diseases)
The extracellular matrix (ECM) is a network of different proteins and proteoglycans that controls differentiation, migration, repair, survival, and development, and it seems that its remodeling is required for healthy adipose tissue expansion. Obesity drives an excessive lipid accumulation in adipocytes, which provokes immune cells infiltration, fibrosis (an excess of deposition of ECM components such as collagens, elastin, and fibronectin) and inflammation, considered a consequence of local hypoxia, and ultimately insulin resistance. To understand the mechanism of this process is a challenge to treat the metabolic diseases. This review is focused at identifying the putative role of ECM in adipose tissue, describing its structure and components, its main tissue receptors, and how it is affected in obesity, and subsequently the importance of an appropriate ECM remodeling in adipose tissue expansion to prevent metabolic diseases. View Full-Text
Keywords: obesity; adipose tissue; extracellular matrix; insulin resistance obesity; adipose tissue; extracellular matrix; insulin resistance
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MDPI and ACS Style

Ruiz-Ojeda, F.J.; Méndez-Gutiérrez, A.; Aguilera, C.M.; Plaza-Díaz, J. Extracellular Matrix Remodeling of Adipose Tissue in Obesity and Metabolic Diseases. Int. J. Mol. Sci. 2019, 20, 4888. https://doi.org/10.3390/ijms20194888

AMA Style

Ruiz-Ojeda FJ, Méndez-Gutiérrez A, Aguilera CM, Plaza-Díaz J. Extracellular Matrix Remodeling of Adipose Tissue in Obesity and Metabolic Diseases. International Journal of Molecular Sciences. 2019; 20(19):4888. https://doi.org/10.3390/ijms20194888

Chicago/Turabian Style

Ruiz-Ojeda, Francisco J., Andrea Méndez-Gutiérrez, Concepción M. Aguilera, and Julio Plaza-Díaz. 2019. "Extracellular Matrix Remodeling of Adipose Tissue in Obesity and Metabolic Diseases" International Journal of Molecular Sciences 20, no. 19: 4888. https://doi.org/10.3390/ijms20194888

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