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Review

Towards Clinical Translation of CD8+ Regulatory T Cells Restricted by Non-Classical Major Histocompatibility Complex Ib Molecules

1
Department of Medicine, Division of Regenerative Medicine, Loma Linda University, Loma Linda, CA 92354, USA
2
Department of Neurosurgery, the University of Alabama at Birmingham, Birmingham, AL 35294, USA
3
Department of Microbiology, the University of Alabama at Birmingham, Birmingham, AL 35294, USA
4
Department of Biomedical Sciences, College of Veterinary Medicine, Long Island University, Brookville, NY 11548, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(19), 4829; https://doi.org/10.3390/ijms20194829
Received: 29 August 2019 / Revised: 27 September 2019 / Accepted: 27 September 2019 / Published: 28 September 2019
(This article belongs to the Section Molecular Immunology)
In central lymphoid tissues, mature lymphocytes are generated and pathogenic autoreactive lymphocytes are deleted. However, it is currently known that a significant number of potentially pathogenic autoreactive lymphocytes escape the deletion and populate peripheral lymphoid tissues. Therefore, peripheral mechanisms are present to prevent these potentially pathogenic autoreactive lymphocytes from harming one’s own tissues. One such mechanism is dictated by regulatory T (Treg) cells. So far, the most extensively studied Treg cells are CD4+Foxp3+ Treg cells. However, recent clinical trials for the treatment of immune-mediated diseases using CD4+ Foxp3+ Treg cells met with limited success. Accordingly, it is necessary to explore the potential importance of other Treg cells such as CD8+ Treg cells. In this regard, one extensively studied CD8+ Treg cell subset is Qa-1(HLA-E in human)-restricted CD8+ Treg cells, in which Qa-1(HLA-E) molecules belong to a group of non-classical major histocompatibility complex Ib molecules. This review will first summarize the evidence for the presence of Qa-1-restricted CD8+ Treg cells and their regulatory mechanisms. Major discussions will then focus on the potential clinical translation of Qa-1-restricted CD8+ Treg cells. At the end, we will briefly discuss the current status of human studies on HLA-E-restricted CD8+ Treg cells as well as potential future directions. View Full-Text
Keywords: Qa-1; HLA-E; CD8+ Treg cells; non-classical major histocompatibility complex Ib molecules; epitopes; and vaccination Qa-1; HLA-E; CD8+ Treg cells; non-classical major histocompatibility complex Ib molecules; epitopes; and vaccination
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MDPI and ACS Style

Wasnik, S.; Baylink, D.J.; Leavenworth, J.; Liu, C.; Bi, H.; Tang, X. Towards Clinical Translation of CD8+ Regulatory T Cells Restricted by Non-Classical Major Histocompatibility Complex Ib Molecules. Int. J. Mol. Sci. 2019, 20, 4829. https://doi.org/10.3390/ijms20194829

AMA Style

Wasnik S, Baylink DJ, Leavenworth J, Liu C, Bi H, Tang X. Towards Clinical Translation of CD8+ Regulatory T Cells Restricted by Non-Classical Major Histocompatibility Complex Ib Molecules. International Journal of Molecular Sciences. 2019; 20(19):4829. https://doi.org/10.3390/ijms20194829

Chicago/Turabian Style

Wasnik, Samiksha; Baylink, David J.; Leavenworth, Jianmei; Liu, Chenfan; Bi, Hongzheng; Tang, Xiaolei. 2019. "Towards Clinical Translation of CD8+ Regulatory T Cells Restricted by Non-Classical Major Histocompatibility Complex Ib Molecules" Int. J. Mol. Sci. 20, no. 19: 4829. https://doi.org/10.3390/ijms20194829

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