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Epigenetic Alterations of Heat Shock Proteins (HSPs) in Cancer

by 1,†, Tae-Su Han 1,†, Keun Hur 2,* and Hyun-Soo Cho 1,*
Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea
Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu 41944, Korea
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(19), 4758;
Received: 22 August 2019 / Revised: 20 September 2019 / Accepted: 23 September 2019 / Published: 25 September 2019
(This article belongs to the Special Issue Molecular Chaperones 2.0)
Heat shock proteins (HSPs) are associated with various physiological processes (protein refolding and degradation) involved in the responses to cellular stress, such as cytotoxic agents, high temperature, and hypoxia. HSPs are overexpressed in cancer cells and play roles in their apoptosis, invasion, proliferation, angiogenesis, and metastasis. The regulation or translational modification of HSPs is recognized as a therapeutic target for the development of anticancer drugs. Among the regulatory processes associated with HSP expression, the epigenetic machinery (miRNAs, histone modification, and DNA methylation) has key functions in cancer. Moreover, various epigenetic modifiers of HSP expression have also been reported as therapeutic targets and diagnostic markers of cancer. Thus, in this review, we describe the epigenetic alterations of HSP expression in cancer cells and suggest that HSPs be clinically applied as diagnostic and therapeutic markers in cancer therapy via controlled epigenetic modifiers. View Full-Text
Keywords: HSPs; epigenetics; miRNA; DNA methylation; histone methylation; cancer HSPs; epigenetics; miRNA; DNA methylation; histone methylation; cancer
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Ban, H.S.; Han, T.-S.; Hur, K.; Cho, H.-S. Epigenetic Alterations of Heat Shock Proteins (HSPs) in Cancer. Int. J. Mol. Sci. 2019, 20, 4758.

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