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The Role of MMP8 in Cancer: A Systematic Review

by 1,2, 3,4, 1,2,5,6,7,*, 1,2,8 and 1,2,3,4
1
Cancer and Translational Medicine Research Unit, Faculty of Medicine, University of Oulu, 90014 Oulu, Finland
2
Medical Research Center Oulu, Oulu University Hospital and University of Oulu, 90220 Oulu, Finland
3
Department of Oral Biological & Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC V6T 1Z2, Canada
4
Centre for Blood Research, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
5
Department of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland
6
Helsinki University Hospital, 00014 Helsinki, Finland
7
Translational Immunology Research Program (TRIMM), University of Helsinki, 00014 Helsinki, Finland
8
Biobank Borealis of Northern Finland, Oulu University Hospital, 90220 Oulu, Finland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(18), 4506; https://doi.org/10.3390/ijms20184506
Received: 14 August 2019 / Revised: 6 September 2019 / Accepted: 8 September 2019 / Published: 11 September 2019
(This article belongs to the Section Molecular Oncology)
Matrix metalloproteinases (MMPs) have traditionally been considered as tumor promoting enzymes as they degrade extracellular matrix components, thus increasing the invasion of cancer cells. It has become evident, however, that MMPs can also cleave and alter the function of various non-matrix bioactive molecules, leading to both tumor promoting and suppressive effects. We applied systematic review guidelines to study MMP8 in cancer including the use of MMP8 as a prognostic factor or as a target/anti-target in cancer treatment, and its molecular mechanisms. A total of 171 articles met the inclusion criteria. The collective evidence reveals that in breast, skin and oral tongue cancer, MMP8 inhibits cancer cell invasion and proliferation, and protects patients from metastasis via cleavage of non-structural substrates. Conversely, in liver and gastric cancers, high levels of MMP8 worsen the prognosis. Expression and genetic alterations of MMP8 can be used as a prognostic factor by examination of the tumor and serum/plasma. We conclude, that MMP8 has differing effects on cancers depending on their tissue of origin. The use of MMP8 as a prognostic factor alone, or with other factors, seems to have potential. The molecular mechanisms of MMP8 in cancer further emphasize its role as an important regulator of bioactive molecules. View Full-Text
Keywords: matrix metalloproteinase 8; cancer; prognosis; molecular mechanism; cancer drug therapy; systematic review matrix metalloproteinase 8; cancer; prognosis; molecular mechanism; cancer drug therapy; systematic review
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MDPI and ACS Style

Juurikka, K.; Butler, G.S.; Salo, T.; Nyberg, P.; Åström, P. The Role of MMP8 in Cancer: A Systematic Review. Int. J. Mol. Sci. 2019, 20, 4506.

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