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Chromatin Remodeling and Epigenetic Regulation in Plant DNA Damage Repair
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DNA- and DNA-Protein-Crosslink Repair in Plants

Botanical Institute, Molecular Biology and Biochemistry, Karlsruhe Institute of Technology, Fritz-Haber-Weg 4, 76131 Karlsruhe, Germany
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(17), 4304;
Received: 31 July 2019 / Revised: 30 August 2019 / Accepted: 1 September 2019 / Published: 3 September 2019
(This article belongs to the Special Issue DNA Damage and Repair in Plants)
DNA-crosslinks are one of the most severe types of DNA lesions. Crosslinks (CLs) can be subdivided into DNA-intrastrand CLs, DNA-interstrand CLs (ICLs) and DNA-protein crosslinks (DPCs), and arise by various exogenous and endogenous sources. If left unrepaired before the cell enters S-phase, ICLs and DPCs pose a major threat to genomic integrity by blocking replication. In order to prevent the collapse of replication forks and impairment of cell division, complex repair pathways have emerged. In mammals, ICLs are repaired by the so-called Fanconi anemia (FA) pathway, which includes 22 different FANC genes, while in plants only a few of these genes are conserved. In this context, two pathways of ICL repair have been defined, each requiring the interaction of a helicase (FANCJB/RTEL1) and a nuclease (FAN1/MUS81). Moreover, homologous recombination (HR) as well as postreplicative repair factors are also involved. Although DPCs possess a comparable toxic potential to cells, it has only recently been shown that at least three parallel pathways for DPC repair exist in plants, defined by the protease WSS1A, the endonuclease MUS81 and tyrosyl-DNA phosphodiesterase 1 (TDP1). The importance of crosslink repair processes are highlighted by the fact that deficiencies in the respective pathways are associated with diverse hereditary disorders. View Full-Text
Keywords: crosslink repair; DPC; ICL; intrastrand CL; Fanconi Anemia; helicase; protease crosslink repair; DPC; ICL; intrastrand CL; Fanconi Anemia; helicase; protease
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Enderle, J.; Dorn, A.; Puchta, H. DNA- and DNA-Protein-Crosslink Repair in Plants. Int. J. Mol. Sci. 2019, 20, 4304.

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