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Open AccessArticle

Oral Administration of Microencapsulated B. Longum BAA-999 and Lycopene Modulates IGF-1/IGF-1R/IGFBP3 Protein Expressions in a Colorectal Murine Model

1
Graduate Studies in Food Science, School of Chemistry, Autonomous University of Queretaro, Cerro de las Campanas S/N, C.P. 76010 Querétaro, Mexico
2
Chemical Engineering Department, National Technological of Mexico, Tecnológico y Antonio García Cubas S/N C.P. 38010 Guanajuato, Mexico
3
Molecular Immunogenetics Laboratory, National Institute of Pediatrics, Insurgentes Sur 3700-C, Cuicuilco, C.P. 04530 Ciudad de México, Mexico
4
Histoptology Laboratory, School of Medicine, Autonomous University of Queretaro. Clavel 200, Prados de la Capilla, C.P. 76017 Querétaro, Mexico
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(17), 4275; https://doi.org/10.3390/ijms20174275
Received: 19 July 2019 / Revised: 24 August 2019 / Accepted: 29 August 2019 / Published: 31 August 2019
(This article belongs to the Special Issue The Effect of Dietary Factors on Cancer 2.0)
The Insulin-like growth factor-I/Insulin-like growth factor-I receptor (IGF-1/IGF-1R) system is a major determinant in colorectal cancer (CRC) pathogenesis. Probiotics (Bifidobacterium longum, BF) and lycopene (LYC) have been individually researched for their beneficial effects in the prevention of CRC. However, the effect of a combined treatment of microencapsulated BF and LYC on IGF-1/IGF-1R/IGFBPs (Insulin-like growth factor-binding proteins) expression in an azoxymethane (AOM)-dextran sulfate sodium (DSS)-induced CRC model have not been demonstrated. BF was microencapsulated by the spray drying technique, with high viability, and daily gavaged with LYC for 16 weeks to CD-1 mice in an AOM-DSS model. The results indicated that BF- and BF + LYC-treated groups had significantly lower inflammation grade, tumor incidence (13–38%) and adenocarcinoma (13–14%) incidence compared to the AOM + DSS group (80%), whereas LYC treatment only protected against inflammation grade and incidence. Caecal, colonic and fecal pH and β-glucuronidase (β-GA) values were significantly normalized by BF and LYC. Similarly, BF and BF + LYC treatments significantly reduced both the positive rate and expression grade of IGF-1 and IGF-1R proteins and normalized Insulin-like growth factor-binding protein-3 (IGFBP3) expression. Based on intestinal parameters related to the specific colon carcinogenesis in an AOM-DSS-induced model, LYC and microencapsulated BF supplementation resulted in a significant chemopreventive potential through the modulation of IGF-1/IGF-1R system. View Full-Text
Keywords: B. longum microencapsulated; gastrointestinal bacterial distribution; lycopene; IGF-1/IGF-1R/IGFBPs system; colorectal cancer B. longum microencapsulated; gastrointestinal bacterial distribution; lycopene; IGF-1/IGF-1R/IGFBPs system; colorectal cancer
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Valadez-Bustos, N.; Escamilla-Silva, E.M.; García-Vázquez, F.J.; Gallegos-Corona, M.A.; Amaya-Llano, S.L.; Ramos-Gómez, M. Oral Administration of Microencapsulated B. Longum BAA-999 and Lycopene Modulates IGF-1/IGF-1R/IGFBP3 Protein Expressions in a Colorectal Murine Model. Int. J. Mol. Sci. 2019, 20, 4275.

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