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3dRNA v2.0: An Updated Web Server for RNA 3D Structure Prediction

School of Physics and Key Laboratory of Molecular Biophysics of the Ministry of Education, Huazhong University of Science and Technology, Wuhan 430074, China
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Int. J. Mol. Sci. 2019, 20(17), 4116; https://doi.org/10.3390/ijms20174116
Received: 9 May 2019 / Revised: 11 August 2019 / Accepted: 15 August 2019 / Published: 23 August 2019
(This article belongs to the Special Issue RNA Structure Prediction)
3D structures of RNAs are the basis for understanding their biological functions. However, experimentally solved RNA 3D structures are very limited in comparison with known RNA sequences up to now. Therefore, many computational methods have been proposed to solve this problem, including our 3dRNA. In recent years, 3dRNA has been greatly improved by adding several important features, including structure sampling, structure ranking and structure optimization under residue-residue restraints. Particularly, the optimization procedure with restraints enables 3dRNA to treat pseudoknots in a new way. These new features of 3dRNA can greatly promote its performance and have been integrated into the 3dRNA v2.0 web server. Here we introduce these new features in the 3dRNA v2.0 web server for the users. View Full-Text
Keywords: RNA structure prediction; scoring function; structure optimization RNA structure prediction; scoring function; structure optimization
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Wang, J.; Wang, J.; Huang, Y.; Xiao, Y. 3dRNA v2.0: An Updated Web Server for RNA 3D Structure Prediction. Int. J. Mol. Sci. 2019, 20, 4116.

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