Developing Regenerative Treatments for Developmental Defects, Injuries, and Diseases Using Extracellular Matrix Collagen-Targeting Peptides

Goldbloom-Helzner, Leora; Hao, Dake; Wang, Aijun

doi:10.3390/ijms20174072

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Developing Regenerative Treatments for Developmental Defects, Injuries, and Diseases Using Extracellular Matrix Collagen-Targeting Peptides

Leora Goldbloom-Helzner

^1,2,3,

Dake Hao

^1,2,3 and

Aijun Wang

^1,2,3,*

Surgical Bioengineering Laboratory, Department of Surgery, School of Medicine, University of California Davis, Sacramento, CA 95817, USA

Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA

Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children, Sacramento, CA 95817, USA

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2019, 20(17), 4072; https://doi.org/10.3390/ijms20174072

Received: 30 July 2019 / Revised: 19 August 2019 / Accepted: 20 August 2019 / Published: 21 August 2019

(This article belongs to the Special Issue Extracellular Matrix in Development and Disease 2.0)

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Abstract

Collagen is the most widespread extracellular matrix (ECM) protein in the body and is important in maintaining the functionality of organs and tissues. Studies have explored interventions using collagen-targeting tissue engineered techniques, using collagen hybridizing or collagen binding peptides, to target or treat dysregulated or injured collagen in developmental defects, injuries, and diseases. Researchers have used collagen-targeting peptides to deliver growth factors, drugs, and genetic materials, to develop bioactive surfaces, and to detect the distribution and status of collagen. All of these approaches have been used for various regenerative medicine applications, including neovascularization, wound healing, and tissue regeneration. In this review, we describe in depth the collagen-targeting approaches for regenerative therapeutics and compare the benefits of using the different molecules for various present and future applications. View Full-Text

Keywords: collagen; extracellular matrix; tissue engineering; regenerative medicine; collagen hybridizing peptide

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

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MDPI and ACS Style

Goldbloom-Helzner, L.; Hao, D.; Wang, A. Developing Regenerative Treatments for Developmental Defects, Injuries, and Diseases Using Extracellular Matrix Collagen-Targeting Peptides. Int. J. Mol. Sci. 2019, 20, 4072. https://doi.org/10.3390/ijms20174072

AMA Style

Goldbloom-Helzner L, Hao D, Wang A. Developing Regenerative Treatments for Developmental Defects, Injuries, and Diseases Using Extracellular Matrix Collagen-Targeting Peptides. International Journal of Molecular Sciences. 2019; 20(17):4072. https://doi.org/10.3390/ijms20174072

Chicago/Turabian Style

Goldbloom-Helzner, Leora, Dake Hao, and Aijun Wang. 2019. "Developing Regenerative Treatments for Developmental Defects, Injuries, and Diseases Using Extracellular Matrix Collagen-Targeting Peptides" International Journal of Molecular Sciences 20, no. 17: 4072. https://doi.org/10.3390/ijms20174072

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Developing Regenerative Treatments for Developmental Defects, Injuries, and Diseases Using Extracellular Matrix Collagen-Targeting Peptides

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