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Regulation of Wound Healing by the NRF2 Transcription Factor—More Than Cytoprotection

Institute for Molecular Health Sciences, Department of Biology, Swiss Federal Institute of Technology Zürich, 8093 Zurich, Switzerland
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Int. J. Mol. Sci. 2019, 20(16), 3856; https://doi.org/10.3390/ijms20163856
Received: 17 July 2019 / Revised: 5 August 2019 / Accepted: 7 August 2019 / Published: 8 August 2019
(This article belongs to the Special Issue The Nrf2 pathway: regulation, functions, and potential applications)
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Abstract

The nuclear factor-erythroid 2-related factor 2 (NRF2) transcription factor plays a central role in mediating the cellular stress response. Due to their antioxidant properties, compounds activating NRF2 have received much attention as potential medications for disease prevention, or even for therapy. Accumulating evidence suggests that activation of the NRF2 pathway also has a major impact on wound healing and may be beneficial in the treatment of chronic wounds, which remain a considerable health and economic burden. While NRF2 activation indeed shows promise, important considerations need to be made in light of corresponding evidence that also points towards pro-tumorigenic effects of NRF2. In this review, we discuss the evidence to date, highlighting recent advances using gain- and loss-of-function animal models and how these data fit with observations in humans. View Full-Text
Keywords: NRF2; wound healing; keratinocyte; fibroblast; inflammation NRF2; wound healing; keratinocyte; fibroblast; inflammation
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Hiebert, P.; Werner, S. Regulation of Wound Healing by the NRF2 Transcription Factor—More Than Cytoprotection. Int. J. Mol. Sci. 2019, 20, 3856.

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