Next Article in Journal
Regulation of Brain Cholesterol: What Role Do Liver X Receptors Play in Neurodegenerative Diseases?
Next Article in Special Issue
The Role of Nrf2 in the Antioxidant Cellular Response to Medical Ozone Exposure
Previous Article in Journal
Enzymatic Biotransformation of Balloon Flower Root Saponins into Bioactive Platycodin D by Deglucosylation with Caldicellulosiruptor bescii β-Glucosidase
Previous Article in Special Issue
Polymorphism in the Promoter Region of NFE2L2 Gene Is a Genetic Marker of Susceptibility to Cirrhosis Associated with Alcohol Abuse
Article Menu

Export Article

Open AccessReview

Regulation of Wound Healing by the NRF2 Transcription Factor—More Than Cytoprotection

Institute for Molecular Health Sciences, Department of Biology, Swiss Federal Institute of Technology Zürich, 8093 Zurich, Switzerland
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(16), 3856;
Received: 17 July 2019 / Revised: 5 August 2019 / Accepted: 7 August 2019 / Published: 8 August 2019
(This article belongs to the Special Issue The Nrf2 pathway: regulation, functions, and potential applications)
PDF [856 KB, uploaded 8 August 2019]
  |     |  


The nuclear factor-erythroid 2-related factor 2 (NRF2) transcription factor plays a central role in mediating the cellular stress response. Due to their antioxidant properties, compounds activating NRF2 have received much attention as potential medications for disease prevention, or even for therapy. Accumulating evidence suggests that activation of the NRF2 pathway also has a major impact on wound healing and may be beneficial in the treatment of chronic wounds, which remain a considerable health and economic burden. While NRF2 activation indeed shows promise, important considerations need to be made in light of corresponding evidence that also points towards pro-tumorigenic effects of NRF2. In this review, we discuss the evidence to date, highlighting recent advances using gain- and loss-of-function animal models and how these data fit with observations in humans. View Full-Text
Keywords: NRF2; wound healing; keratinocyte; fibroblast; inflammation NRF2; wound healing; keratinocyte; fibroblast; inflammation

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Hiebert, P.; Werner, S. Regulation of Wound Healing by the NRF2 Transcription Factor—More Than Cytoprotection. Int. J. Mol. Sci. 2019, 20, 3856.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top