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Periodontal Therapy for Improving Lipid Profiles in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

1
The University of Sydney School of Dentistry, Faculty of Medicine and Health, The University of Sydney, Camperdown 2006, Australia
2
Westmead Applied Research Centre, Sydney Medical School, Westmead 2145, Australia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(15), 3826; https://doi.org/10.3390/ijms20153826
Received: 13 June 2019 / Revised: 30 July 2019 / Accepted: 31 July 2019 / Published: 5 August 2019
(This article belongs to the Special Issue Oral Inflammations and Systemic Diseases)
Periodontitis is a chronic inflammatory disorder often seen in patients with diabetes mellitus (DM). Individuals with diabetes are at a greater risk of developing cardiovascular complications and this may be related, in part, to lipid abnormalities observed in these individuals. The objective of this systematic review is to compile the current scientific evidence of the effects of periodontal treatment on lipid profiles in patients with type 2 diabetes mellitus. Through a systematic search using MEDLINE, EMBASE, PubMed, and Web of Science, 313 articles were identified. Of these, seven clinical trials which met all inclusion criteria were chosen for analysis. Between baseline and 3-month follow-up, there was a statistically significant reduction in the levels of total cholesterol (mean differences (MD) −0.47 mmol/L (95% confidence interval (CI), −0.75, −0.18, p = 0.001)), triglycerides (MD −0.20 mmol/L (95% CI −0.24, −0.16, p < 0.00001)) favouring the intervention arm, and a statistically significant reduction in levels of high density lipoprotein (HDL) (MD 0.06 mmol/L (95% CI 0.03, 0.08, p < 0.00001)) favouring the control arm. No significant differences were observed between baseline and 6-month follow-up levels for any lipid analysed. The heterogeneity between studies was high. This review foreshadows a potential benefit of periodontal therapy for lipid profiles in patients suffering from type 2 DM, however, well designed clinical trials using lipid profiles as primary outcome measures are warranted. View Full-Text
Keywords: periodontal therapy; type 2 diabetes mellitus; lipid profiles; inflammation periodontal therapy; type 2 diabetes mellitus; lipid profiles; inflammation
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Garde, S.; Akhter, R.; Nguyen, M.A.; Chow, C.K.; Eberhard, J. Periodontal Therapy for Improving Lipid Profiles in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Int. J. Mol. Sci. 2019, 20, 3826.

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