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Stable Adult Hippocampal Neurogenesis in Cannabinoid Receptor CB2 Deficient Mice

Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), 20246 Hamburg, Germany
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Int. J. Mol. Sci. 2019, 20(15), 3759; https://doi.org/10.3390/ijms20153759
Received: 21 June 2019 / Revised: 19 July 2019 / Accepted: 24 July 2019 / Published: 1 August 2019
The G-protein coupled cannabinoid receptor 2 (CB2) has been implicated in the regulation of adult neurogenesis in the hippocampus. The contribution of CB2 towards basal levels of proliferation and the number of neural progenitors in the subgranular zone (SGZ) of the dentate gyrus, however, remain unclear. We stained hippocampal brain sections of 16- to 17-week-old wildtype and CB2-deficient mice, for neural progenitor and immature neuron markers doublecortin (DCX) and calretinin (CR) and for the proliferation marker Ki67 and quantified the number of positive cells in the SGZ. The quantification revealed that CB2 deficiency neither altered overall cell proliferation nor the size of the DCX+ or DCX and CR double-positive populations in the SGZ compared to control animals. The results indicate that CB2 might not contribute to basal levels of adult neurogenesis in four-month-old healthy mice. CB2 signaling might be more relevant in conditions where adult neurogenesis is dynamically regulated, such as neuroinflammation. View Full-Text
Keywords: G-protein coupled receptor; adult neurogenesis; cannabinoid receptor; CB2; dentate gyrus; subgranular zone; DCX; Ki67; calretinin G-protein coupled receptor; adult neurogenesis; cannabinoid receptor; CB2; dentate gyrus; subgranular zone; DCX; Ki67; calretinin
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Mensching, L.; Djogo, N.; Keller, C.; Rading, S.; Karsak, M. Stable Adult Hippocampal Neurogenesis in Cannabinoid Receptor CB2 Deficient Mice. Int. J. Mol. Sci. 2019, 20, 3759.

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