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Endothelium-Dependent Hyperpolarization (EDH) in Diabetes: Mechanistic Insights and Therapeutic Implications

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
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Int. J. Mol. Sci. 2019, 20(15), 3737; https://doi.org/10.3390/ijms20153737
Received: 3 July 2019 / Revised: 25 July 2019 / Accepted: 30 July 2019 / Published: 31 July 2019
(This article belongs to the Special Issue Calcium Signaling in Human Health and Diseases 2.0)
Diabetes mellitus is one of the major risk factors for cardiovascular disease and is an important health issue worldwide. Long-term diabetes causes endothelial dysfunction, which in turn leads to diabetic vascular complications. Endothelium-derived nitric oxide is a major vasodilator in large-size vessels, and the hyperpolarization of vascular smooth muscle cells mediated by the endothelium plays a central role in agonist-mediated and flow-mediated vasodilation in resistance-size vessels. Although the mechanisms underlying diabetic vascular complications are multifactorial and complex, impairment of endothelium-dependent hyperpolarization (EDH) of vascular smooth muscle cells would contribute at least partly to the initiation and progression of microvascular complications of diabetes. In this review, we present the current knowledge about the pathophysiology and underlying mechanisms of impaired EDH in diabetes in animals and humans. We also discuss potential therapeutic approaches aimed at the prevention and restoration of EDH in diabetes. View Full-Text
Keywords: antidiabetic agent; Ca2+-activated K+ channel; diabetes mellitus; endothelial function; endothelium-dependent hyperpolarization; endothelium-derived hyperpolarizing factor; gap junction; reactive oxygen species antidiabetic agent; Ca2+-activated K+ channel; diabetes mellitus; endothelial function; endothelium-dependent hyperpolarization; endothelium-derived hyperpolarizing factor; gap junction; reactive oxygen species
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MDPI and ACS Style

Goto, K.; Kitazono, T. Endothelium-Dependent Hyperpolarization (EDH) in Diabetes: Mechanistic Insights and Therapeutic Implications. Int. J. Mol. Sci. 2019, 20, 3737. https://doi.org/10.3390/ijms20153737

AMA Style

Goto K, Kitazono T. Endothelium-Dependent Hyperpolarization (EDH) in Diabetes: Mechanistic Insights and Therapeutic Implications. International Journal of Molecular Sciences. 2019; 20(15):3737. https://doi.org/10.3390/ijms20153737

Chicago/Turabian Style

Goto, Kenichi; Kitazono, Takanari. 2019. "Endothelium-Dependent Hyperpolarization (EDH) in Diabetes: Mechanistic Insights and Therapeutic Implications" Int. J. Mol. Sci. 20, no. 15: 3737. https://doi.org/10.3390/ijms20153737

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