Next Article in Journal
Differential Protein Expression Profiles of Bronchoalveolar Lavage Fluid Following Lipopolysaccharide-Induced Direct and Indirect Lung Injury in Mice
Previous Article in Journal
Novel Phototransformable Fluorescent Protein SAASoti with Unique Photochemical Properties
Previous Article in Special Issue
Multidisciplinary Challenges in Mastocytosis and How to Address with Personalized Medicine Approaches
Article Menu

Export Article

Version is current.

Open AccessReview

Coeliac Disease and Mast Cells

Department of Medical and Biological Science, University of Udine, 33100 Udine, Italy
Second Unit of Internal Medicine, University Hospital of Udine, 33100 Udine, Italy
Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University Hospital of Florence, 50134 Florence, Italy
Tuscany Referral Center for Adult Coeliac Disease, AOU Careggi, 50134 Florence, Italy
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(14), 3400;
Received: 13 May 2019 / Revised: 5 July 2019 / Accepted: 8 July 2019 / Published: 11 July 2019
(This article belongs to the Special Issue Mast Cells in Health and Disease)
PDF [2169 KB, uploaded 11 July 2019]


Over the last decades, there has been an impressive progress in our understanding of coeliac disease pathogenesis and it has become clear that the disorder is the final result of complex interactions of environmental, genetic, and immunological factors. Coeliac disease is now considered a prototype of T-cell-mediated disease characterized by loss of tolerance to dietary gluten and the targeted killing of enterocytes by T-cell receptor αβ intraepithelial lymphocytes. Accumulating evidence, however, indicates that the induction of a gluten-specific T helper-1 response must be preceded by the activation of the innate immune system. Mast cells are key players of the innate immune response and contribute to the pathogenesis of a multitude of diseases. Here, we review the results of studies aimed at investigating the role of mast cells in the pathogenesis of coeliac disease, showing that these cells increase in number during the progression of the disease and contribute to define a pro-inflammatory microenvironment. View Full-Text
Keywords: mast cells; coeliac disease; gliadin immunology; p31-43 fragment; 33-mer peptide; 25-mer fragment mast cells; coeliac disease; gliadin immunology; p31-43 fragment; 33-mer peptide; 25-mer fragment

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Frossi, B.; De Carli, M.; Calabrò, A. Coeliac Disease and Mast Cells. Int. J. Mol. Sci. 2019, 20, 3400.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top