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Coeliac Disease and Mast Cells

1
Department of Medical and Biological Science, University of Udine, 33100 Udine, Italy
2
Second Unit of Internal Medicine, University Hospital of Udine, 33100 Udine, Italy
3
Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University Hospital of Florence, 50134 Florence, Italy
4
Tuscany Referral Center for Adult Coeliac Disease, AOU Careggi, 50134 Florence, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(14), 3400; https://doi.org/10.3390/ijms20143400
Received: 13 May 2019 / Revised: 5 July 2019 / Accepted: 8 July 2019 / Published: 11 July 2019
(This article belongs to the Special Issue Mast Cells in Health and Disease)
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PDF [2169 KB, uploaded 11 July 2019]
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Abstract

Over the last decades, there has been an impressive progress in our understanding of coeliac disease pathogenesis and it has become clear that the disorder is the final result of complex interactions of environmental, genetic, and immunological factors. Coeliac disease is now considered a prototype of T-cell-mediated disease characterized by loss of tolerance to dietary gluten and the targeted killing of enterocytes by T-cell receptor αβ intraepithelial lymphocytes. Accumulating evidence, however, indicates that the induction of a gluten-specific T helper-1 response must be preceded by the activation of the innate immune system. Mast cells are key players of the innate immune response and contribute to the pathogenesis of a multitude of diseases. Here, we review the results of studies aimed at investigating the role of mast cells in the pathogenesis of coeliac disease, showing that these cells increase in number during the progression of the disease and contribute to define a pro-inflammatory microenvironment. View Full-Text
Keywords: mast cells; coeliac disease; gliadin immunology; p31-43 fragment; 33-mer peptide; 25-mer fragment mast cells; coeliac disease; gliadin immunology; p31-43 fragment; 33-mer peptide; 25-mer fragment
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Frossi, B.; De Carli, M.; Calabrò, A. Coeliac Disease and Mast Cells. Int. J. Mol. Sci. 2019, 20, 3400.

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