Protective Effects of Salidroside against Carbon Tetrachloride (CCl4)-Induced Liver Injury by Initiating Mitochondria to Resist Oxidative Stress in Mice
by
Shi-Yu Lin 1, Dan Xu 1, Xia-Xia Du 1, Chong-Lin Ran 1, Lu Xu 1, Shao-Jun Ren 1, Zi-Ting Tang 1, Li-Zi Yin 1, Chang-Liang He 1, Zhi-Xiang Yuan 1
, Hua-Lin Fu 1, Xiao-Ling Zhao 2 and Gang Shu 1,*
Shi-Yu Lin 1, Dan Xu 1, Xia-Xia Du 1, Chong-Lin Ran 1, Lu Xu 1, Shao-Jun Ren 1, Zi-Ting Tang 1, Li-Zi Yin 1, Chang-Liang He 1, Zhi-Xiang Yuan 1, Hua-Lin Fu 1, Xiao-Ling Zhao 2 and Gang Shu 1,*
1
Department of Pharmacy, Veterinary Medicine College of Sichuan Agricultural University, Chengdu 611130, China
2
Department of Animal Science, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(13), 3187; https://doi.org/10.3390/ijms20133187
Received: 12 March 2019 / Revised: 22 June 2019 / Accepted: 24 June 2019 / Published: 28 June 2019
(This article belongs to the Special Issue Biochemistry, Molecular Biology and Toxicology of Natural and Synthetic Toxins)
The antioxidant effect of salidroside has been proven, but its role in liver injury is poorly understood. In this study, we aimed to evaluate the protective effects and mechanism of salidroside on liver injury induced by carbon tetrachloride (CCl4) in vivo. Mice were pretreated with salidroside (60 mg/kg, intraperitoneally injected, i.p.) once per day for 14 consecutive days and then administered with CCl4 (15.95 g/kg, i.p.) for 24 h to produce a liver injury model. Salidroside attenuated hepatic transaminase elevation in serum and ameliorated liver steatosis and necrosis, thereby suggesting its protective effect on the liver. Salidroside antagonized CCl4-induced toxicity by equilibrating antioxidation system, thereby inhibiting reactive oxygen species accumulation, and restoring mitochondrial structure and function. Salidroside exerts antioxidant and liver-protective effects by selectively inhibiting the activation of genes, including growth arrest and DNA -damage-inducible 45 α (Gadd45a), mitogen-activated protein kinase 7 (Mapk7), and related RAS viral oncogene homolog 2 (Rras2), which induce oxidative stress in the mitogen-activated protein kinase pathway. These results revealed that salidroside can protect the liver from CCl4-induced injury by resisting oxidative stress and protecting mitochondrial function.
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Keywords:
Salidroside; CCl4; liver injury; mitochondria; oxidative stress
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Lin, S.-Y.; Xu, D.; Du, X.-X.; Ran, C.-L.; Xu, L.; Ren, S.-J.; Tang, Z.-T.; Yin, L.-Z.; He, C.-L.; Yuan, Z.-X.; Fu, H.-L.; Zhao, X.-L.; Shu, G. Protective Effects of Salidroside against Carbon Tetrachloride (CCl4)-Induced Liver Injury by Initiating Mitochondria to Resist Oxidative Stress in Mice. Int. J. Mol. Sci. 2019, 20, 3187.
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