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Article

A Novel HIF Inhibitor Halofuginone Prevents Neurodegeneration in a Murine Model of Retinal Ischemia-Reperfusion

1
Department of Ophthalmology, School of Medicine, Keio University, Shinjuku-ku, 160-8582 Tokyo, Japan
2
Laboratory of Photobiology, School of Medicine, Keio University, Shinjuku-ku, 160-8582 Tokyo, Japan
3
Department of Chemistry, School of Medicine, Keio University, Shinjuku-ku, 160-8582 Tokyo, Japan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(13), 3171; https://doi.org/10.3390/ijms20133171
Received: 30 May 2019 / Revised: 23 June 2019 / Accepted: 27 June 2019 / Published: 28 June 2019
Neurodegeneration caused with retinal ischemia or high intraocular pressure is irreversible in general. We have focused on the role of hypoxia-inducible factor (HIF) in retinal homeostasis and revealed that HIF inhibition may be effective against retinal neovascular and neurodegeneration. In this study, we performed in vitro screening of natural products and found halofuginone, which is a derivative of febrifugine extracted from hydrangea, as a novel HIF inhibitor. Administration of halofuginone showed a significant neuroprotective effect by inhibiting HIF-1α expression in a murine retinal ischemia-reperfusion model histologically and functionally. These results indicate that halofuginone can be a neuroprotective agent in ischemic retinal degenerative diseases. View Full-Text
Keywords: HIF-1α; halofuginone; ischemia-reperfusion; neuroprotection HIF-1α; halofuginone; ischemia-reperfusion; neuroprotection
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MDPI and ACS Style

Kunimi, H.; Miwa, Y.; Inoue, H.; Tsubota, K.; Kurihara, T. A Novel HIF Inhibitor Halofuginone Prevents Neurodegeneration in a Murine Model of Retinal Ischemia-Reperfusion. Int. J. Mol. Sci. 2019, 20, 3171. https://doi.org/10.3390/ijms20133171

AMA Style

Kunimi H, Miwa Y, Inoue H, Tsubota K, Kurihara T. A Novel HIF Inhibitor Halofuginone Prevents Neurodegeneration in a Murine Model of Retinal Ischemia-Reperfusion. International Journal of Molecular Sciences. 2019; 20(13):3171. https://doi.org/10.3390/ijms20133171

Chicago/Turabian Style

Kunimi, Hiromitsu, Yukihiro Miwa, Hiroyoshi Inoue, Kazuo Tsubota, and Toshihide Kurihara. 2019. "A Novel HIF Inhibitor Halofuginone Prevents Neurodegeneration in a Murine Model of Retinal Ischemia-Reperfusion" International Journal of Molecular Sciences 20, no. 13: 3171. https://doi.org/10.3390/ijms20133171

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