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Review

Chronic Pain: Structural and Functional Changes in Brain Structures and Associated Negative Affective States

1
Department of Rehabilitation Medicine, Ewha Woman’s University Seoul Hospital, School of Medicine, Ewha Woman’s University, Seoul 07804, Korea
2
Department of Rehabilitation Medicine, College of Medicine, Yeungnam University, Daegu 42415, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(13), 3130; https://doi.org/10.3390/ijms20133130
Received: 28 May 2019 / Revised: 21 June 2019 / Accepted: 25 June 2019 / Published: 26 June 2019
Chronic pain is a condition in which pain progresses from an acute to chronic state and persists beyond the healing process. Chronic pain impairs function and decreases patients’ quality of life. In recent years, efforts have been made to deepen our understanding of chronic pain and to develop better treatments to alleviate chronic pain. In this review, we summarize the results of previous studies, focusing on the mechanisms underlying chronic pain development and the identification of neural areas related to chronic pain. We review the association between chronic pain and negative affective states. Further, we describe the structural and functional changes in brain structures that accompany the chronification of pain and discuss various neurotransmitter families involved. Our review aims to provide guidance for the development of future therapeutic approaches that could be used in the management of chronic pain. View Full-Text
Keywords: chronic pain; central sensitization; negative affective state; corticolimbic system; neurotransmitter chronic pain; central sensitization; negative affective state; corticolimbic system; neurotransmitter
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MDPI and ACS Style

Yang, S.; Chang, M.C. Chronic Pain: Structural and Functional Changes in Brain Structures and Associated Negative Affective States. Int. J. Mol. Sci. 2019, 20, 3130. https://doi.org/10.3390/ijms20133130

AMA Style

Yang S, Chang MC. Chronic Pain: Structural and Functional Changes in Brain Structures and Associated Negative Affective States. International Journal of Molecular Sciences. 2019; 20(13):3130. https://doi.org/10.3390/ijms20133130

Chicago/Turabian Style

Yang, Seoyon, and Min C. Chang 2019. "Chronic Pain: Structural and Functional Changes in Brain Structures and Associated Negative Affective States" International Journal of Molecular Sciences 20, no. 13: 3130. https://doi.org/10.3390/ijms20133130

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