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Translation Control of HAC1 by Regulation of Splicing in Saccharomyces cerevisiae

Department of Biology, University of Ottawa, Marie-Curie Private, Ottawa, ON K1N 9A7, Canada
Int. J. Mol. Sci. 2019, 20(12), 2860; https://doi.org/10.3390/ijms20122860
Received: 22 April 2019 / Revised: 30 May 2019 / Accepted: 10 June 2019 / Published: 12 June 2019
(This article belongs to the Special Issue Translational Control)
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Abstract

Hac1p is a key transcription factor regulating the unfolded protein response (UPR) induced by abnormal accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER) in Saccharomyces cerevisiae. The accumulation of unfolded/misfolded proteins is sensed by protein Ire1p, which then undergoes trans-autophosphorylation and oligomerization into discrete foci on the ER membrane. HAC1 pre-mRNA, which is exported to the cytoplasm but is blocked from translation by its intron sequence looping back to its 5’UTR to form base-pair interaction, is transported to the Ire1p foci to be spliced, guided by a cis-acting bipartite element at its 3’UTR (3’BE). Spliced HAC1 mRNA can be efficiently translated. The resulting Hac1p enters the nucleus and activates, together with coactivators, a large number of genes encoding proteins such as protein chaperones to restore and maintain ER homeostasis and secretary protein quality control. This review details the translation regulation of Hac1p production, mediated by the nonconventional splicing, in the broad context of translation control and summarizes the evolution and diversification of the UPR signaling pathway among fungal, metazoan and plant lineages. View Full-Text
Keywords: HAC1; IRE1; ERN1; XBP1; unfolded protein response; UPR; non-spliceosome splicing; ER stress HAC1; IRE1; ERN1; XBP1; unfolded protein response; UPR; non-spliceosome splicing; ER stress
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Xia, X. Translation Control of HAC1 by Regulation of Splicing in Saccharomyces cerevisiae. Int. J. Mol. Sci. 2019, 20, 2860.

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