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Modern Concepts in Regenerative Therapy for Ischemic Stroke: From Stem Cells for Promoting Angiogenesis to 3D-Bioprinted Scaffolds Customized via Carotid Shear Stress Analysis

Clinic of Cardiology, Cardiac Critical Care Unit, University of Medicine and Pharmacy, Gheorghe Marinescu 38, 540139 Târgu Mureș, Romania
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Int. J. Mol. Sci. 2019, 20(10), 2574; https://doi.org/10.3390/ijms20102574
Received: 1 May 2019 / Revised: 20 May 2019 / Accepted: 22 May 2019 / Published: 25 May 2019
(This article belongs to the Special Issue Head Tissues Regeneration)
Ischemic stroke is associated with a tremendous economic and societal burden, and only a few therapies are currently available for the treatment of this devastating disease. The main therapeutic approaches used nowadays for the treatment of ischemic brain injury aim to achieve reperfusion, neuroprotection and neurorecovery. Therapeutic angiogenesis also seems to represent a promising tool to improve the prognosis of cerebral ischemia. This review aims to present the modern concepts and the current status of regenerative therapy for ischemic stroke and discuss the main results of major clinical trials addressing the effectiveness of stem cell therapy for achieving neuroregeneration in ischemic stroke. At the same time, as a glimpse into the future, this article describes modern concepts for stroke prevention, such as the implantation of bioprinted scaffolds seeded with stem cells, whose 3D geometry is customized according to carotid shear stress. View Full-Text
Keywords: ischemic stroke; endothelial shear stress; neuroprotection; neuroregeneration; 3D-bioprinted scaffolds; stem cells; regenerative therapy ischemic stroke; endothelial shear stress; neuroprotection; neuroregeneration; 3D-bioprinted scaffolds; stem cells; regenerative therapy
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Benedek, A.; Cernica, D.; Mester, A.; Opincariu, D.; Hodas, R.; Rodean, I.; Keri, J.; Benedek, T. Modern Concepts in Regenerative Therapy for Ischemic Stroke: From Stem Cells for Promoting Angiogenesis to 3D-Bioprinted Scaffolds Customized via Carotid Shear Stress Analysis. Int. J. Mol. Sci. 2019, 20, 2574.

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