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Open AccessArticle

Accumulation of Innate Amyloid Beta Peptide in Glioblastoma Tumors

1
Department of Biochemistry, School of Medicine, Universidad Central del Caribe, PO Box 60327, Bayamon, PR 00960-6032, USA
2
Department of Physiology, School of Medicine, Universidad Central del Caribe, PO Box 60327, Bayamon, PR 00960-6032, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(10), 2482; https://doi.org/10.3390/ijms20102482
Received: 8 April 2019 / Revised: 23 April 2019 / Accepted: 15 May 2019 / Published: 20 May 2019
(This article belongs to the Special Issue Peptides for Health Benefits 2019)
Immunostaining with specific antibodies has shown that innate amyloid beta (Aβ) is accumulated naturally in glioma tumors and nearby blood vessels in a mouse model of glioma. In immunofluorescence images, Aβ peptide coincides with glioma cells, and enzyme-linked immunosorbent assay (ELISA) have shown that Aβ peptide is enriched in the membrane protein fraction of tumor cells. ELISAs have also confirmed that the Aβ(1–40) peptide is enriched in glioma tumor areas relative to healthy brain areas. Thioflavin staining revealed that at least some amyloid is present in glioma tumors in aggregated forms. We may suggest that the presence of aggregated amyloid in glioma tumors together with the presence of Aβ immunofluorescence coinciding with glioma cells and the nearby vasculature imply that the source of Aβ peptides in glioma can be systemic Aβ from blood vessels, but this question remains unresolved and needs additional studies. View Full-Text
Keywords: amyloid; Aβ peptide; glioma; platelets amyloid; Aβ peptide; glioma; platelets
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MDPI and ACS Style

Kucheryavykh, L.Y.; Ortiz-Rivera, J.; Kucheryavykh, Y.V.; Zayas-Santiago, A.; Diaz-Garcia, A.; Inyushin, M.Y. Accumulation of Innate Amyloid Beta Peptide in Glioblastoma Tumors. Int. J. Mol. Sci. 2019, 20, 2482. https://doi.org/10.3390/ijms20102482

AMA Style

Kucheryavykh LY, Ortiz-Rivera J, Kucheryavykh YV, Zayas-Santiago A, Diaz-Garcia A, Inyushin MY. Accumulation of Innate Amyloid Beta Peptide in Glioblastoma Tumors. International Journal of Molecular Sciences. 2019; 20(10):2482. https://doi.org/10.3390/ijms20102482

Chicago/Turabian Style

Kucheryavykh, Lilia Y.; Ortiz-Rivera, Jescelica; Kucheryavykh, Yuriy V.; Zayas-Santiago, Astrid; Diaz-Garcia, Amanda; Inyushin, Mikhail Y. 2019. "Accumulation of Innate Amyloid Beta Peptide in Glioblastoma Tumors" Int. J. Mol. Sci. 20, no. 10: 2482. https://doi.org/10.3390/ijms20102482

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