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Autologous cord blood in children with cerebral palsy: a review

1
Polski Bank Komórek Macierzystych S.A. (FamiCord Group), Jana Pawła II 29, 00-867 Warsaw, Poland
2
Sevibe Cells, Parc Científic i Tecnològic de la UdG, C/Pic de Peguera No. 11, 17003 Girona, Spain
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(10), 2433; https://doi.org/10.3390/ijms20102433
Received: 26 March 2019 / Revised: 11 May 2019 / Accepted: 12 May 2019 / Published: 16 May 2019
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
PDF [383 KB, uploaded 16 May 2019]

Abstract

The aim of this narrative review is to report on the current knowledge regarding the clinical use of umbilical cord blood (CB) based on articles from PubMed and clinical trials registered on ClinicalTrials.gov. An increasing amount of evidence suggests that CB may be used for both early diagnostics and treatment of cerebral palsy. The acidity of CB and its biochemical parameters, including dozens of cytokines, growth factors, and other metabolites (such as amino acids, acylcarnitines, phosphatidylcholines, succinate, glycerol, 3-hydroxybutyrate, and O-phosphocholine) are predictors of future neurodevelopment. In addition, several clinical studies confirmed the safety and efficacy of CB administration in both autologous and allogeneic models, including a meta-analysis of five clinical trials involving a total of 328 participants. Currently, nine clinical trials assessing the use of autologous umbilical CB in children diagnosed with hypoxic-ischemic encephalopathy or cerebral palsy are in progress. The total population assessed in these trials exceeds 2500 patients.
Keywords: cord blood; stem cells; cellular therapy; cerebral palsy; hypoxia; hypoxic-ischemic encephalopathy; HIE, ischemia; perinatal brain injury; asphyxia cord blood; stem cells; cellular therapy; cerebral palsy; hypoxia; hypoxic-ischemic encephalopathy; HIE, ischemia; perinatal brain injury; asphyxia
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Boruczkowski, D.; Pujal, J.-M.; Zdolińska-Malinowska, I. Autologous cord blood in children with cerebral palsy: a review. Int. J. Mol. Sci. 2019, 20, 2433.

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