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Int. J. Mol. Sci. 2019, 20(1), 95;

Iron Metabolism in Cancer

1,†, 1,2,†, 1,* and 1,*
Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
University of Chinese Academy of Sciences, Beijing 100049, China
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 26 November 2018 / Revised: 21 December 2018 / Accepted: 22 December 2018 / Published: 27 December 2018
(This article belongs to the Special Issue Drug Discovery, Development and Regulatory Affairs)
PDF [2474 KB, uploaded 27 December 2018]
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Demanded as an essential trace element that supports cell growth and basic functions, iron can be harmful and cancerogenic though. By exchanging between its different oxidized forms, iron overload induces free radical formation, lipid peroxidation, DNA, and protein damages, leading to carcinogenesis or ferroptosis. Iron also plays profound roles in modulating tumor microenvironment and metastasis, maintaining genomic stability and controlling epigenetics. in order to meet the high requirement of iron, neoplastic cells have remodeled iron metabolism pathways, including acquisition, storage, and efflux, which makes manipulating iron homeostasis a considerable approach for cancer therapy. Several iron chelators and iron oxide nanoparticles (IONPs) has recently been developed for cancer intervention and presented considerable effects. This review summarizes some latest findings about iron metabolism function and regulation mechanism in cancer and the application of iron chelators and IONPs in cancer diagnosis and therapy. View Full-Text
Keywords: iron homeostasis; cancer; epigenetic regulation; tumor microenvironment; iron manipulating strategies iron homeostasis; cancer; epigenetic regulation; tumor microenvironment; iron manipulating strategies

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Wang, Y.; Yu, L.; Ding, J.; Chen, Y. Iron Metabolism in Cancer. Int. J. Mol. Sci. 2019, 20, 95.

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