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Open AccessReview

Human Exonuclease 1 (EXO1) Regulatory Functions in DNA Replication with Putative Roles in Cancer

1
Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, DK-2200 Copenhagen, Denmark
2
Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(1), 74; https://doi.org/10.3390/ijms20010074
Received: 20 November 2018 / Revised: 12 December 2018 / Accepted: 19 December 2018 / Published: 25 December 2018
(This article belongs to the Special Issue DNA Replication Stress)
Human exonuclease 1 (EXO1), a 5′→3′ exonuclease, contributes to the regulation of the cell cycle checkpoints, replication fork maintenance, and post replicative DNA repair pathways. These processes are required for the resolution of stalled or blocked DNA replication that can lead to replication stress and potential collapse of the replication fork. Failure to restart the DNA replication process can result in double-strand breaks, cell-cycle arrest, cell death, or cellular transformation. In this review, we summarize the involvement of EXO1 in the replication, DNA repair pathways, cell cycle checkpoints, and the link between EXO1 and cancer. View Full-Text
Keywords: DNA repair; double strand break repair; exonuclease 1; EXO1; mismatch repair; MMR; NER; nucleotide excision repair; strand displacements; TLS; translesion DNA synthesis DNA repair; double strand break repair; exonuclease 1; EXO1; mismatch repair; MMR; NER; nucleotide excision repair; strand displacements; TLS; translesion DNA synthesis
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MDPI and ACS Style

Keijzers, G.; Bakula, D.; Petr, M.A.; Madsen, N.G.K.; Teklu, A.; Mkrtchyan, G.; Osborne, B.; Scheibye-Knudsen, M. Human Exonuclease 1 (EXO1) Regulatory Functions in DNA Replication with Putative Roles in Cancer. Int. J. Mol. Sci. 2019, 20, 74.

AMA Style

Keijzers G, Bakula D, Petr MA, Madsen NGK, Teklu A, Mkrtchyan G, Osborne B, Scheibye-Knudsen M. Human Exonuclease 1 (EXO1) Regulatory Functions in DNA Replication with Putative Roles in Cancer. International Journal of Molecular Sciences. 2019; 20(1):74.

Chicago/Turabian Style

Keijzers, Guido; Bakula, Daniela; Petr, Michael A.; Madsen, Nils G.K.; Teklu, Amanuel; Mkrtchyan, Garik; Osborne, Brenna; Scheibye-Knudsen, Morten. 2019. "Human Exonuclease 1 (EXO1) Regulatory Functions in DNA Replication with Putative Roles in Cancer" Int. J. Mol. Sci. 20, no. 1: 74.

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