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Open AccessArticle

The Epithelial-Mesenchymal Transition Initiated by Malignant Ascites Underlies the Transmesothelial Invasion of Ovarian Cancer Cells

1
Department of Hypertensiology, Angiology and Internal Medicine, Poznań University of Medical Sciences, Długa 1/2 Str., 61-848 Poznań, Poland
2
Division of Gynecological Surgery, Poznań University of Medical Sciences, Polna 33 Str., 60-535 Poznań, Poland
3
General Surgery Ward, Medical Centre HCP, 28 czerwca 1956 r. 223/229 Str., 61-485 Poznań, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(1), 137; https://doi.org/10.3390/ijms20010137
Received: 4 November 2018 / Revised: 20 November 2018 / Accepted: 24 November 2018 / Published: 2 January 2019
The role of the epithelial-mesenchymal transition (EMT) in ovarian cancer cell progression is unquestioned. In this report, we describe that malignant ascites, fluid that accumulates in the peritoneal cavity in a large group of patients with ovarian cancer, stimulate EMT in two representative ovarian cancer cell lines (A2780, SKOV-3). In addition, we identify the ascites-derived mediators of EMT and signaling pathways initiated in the cancer cells that underlie this phenomenon. Finally, we demonstrate that EMT induced in the cancer cells in response to the malignant ascites contributes to their increased transmesothelial invasion. Altogether, our study provides new insight into the mechanistic aspects of the malignant ascites-dependent exacerbation of the intraperitoneal progression of ovarian cancer. View Full-Text
Keywords: epithelial-mesenchymal transition; malignant ascites; ovarian cancer epithelial-mesenchymal transition; malignant ascites; ovarian cancer
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Pakuła, M.; Mikuła-Pietrasik, J.; Witucka, A.; Kostka-Jeziorny, K.; Uruski, P.; Moszyński, R.; Naumowicz, E.; Sajdak, S.; Tykarski, A.; Książek, K. The Epithelial-Mesenchymal Transition Initiated by Malignant Ascites Underlies the Transmesothelial Invasion of Ovarian Cancer Cells. Int. J. Mol. Sci. 2019, 20, 137.

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