Next Article in Journal
Interaction of Diet and Ozone Exposure on Oxidative Stress Parameters within Specific Brain Regions of Male Brown Norway Rats
Previous Article in Journal
Olive Oil, Palm Oil, and Hybrid Palm Oil Distinctly Modulate Liver Transcriptome and Induce NAFLD in Mice Fed a High-Fat Diet
Previous Article in Special Issue
Hyaluronic Acid-Decorated Chitosan Nanoparticles for CD44-Targeted Delivery of Everolimus
Open AccessArticle

Glycopolymer Grafted Silica Gel as Chromatographic Packing Materials

School of Chemical Engineering, Xiangtan University, Xiangtan 411105, China
CAS Key Laboratory of Bio-Based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT), Chinese Academy of Sciences (CAS), Qingdao 266101, China
University of Chinese Academy of Sciences, Shijingshan District, Beijing 100049, China
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(1), 10;
Received: 31 October 2018 / Revised: 14 December 2018 / Accepted: 18 December 2018 / Published: 20 December 2018
(This article belongs to the Special Issue Smart Polymers for Biomedical Applications)
The modification of the surface of silica gel to prepare hydrophilic chromatographic fillers has recently become a research interest. Most researchers have grafted natural sugar-containing polymers onto chromatographic surfaces. The disadvantage of this approach is that the packing structure is singular and the application scope is limited. In this paper, we explore the innovative technique of grafting a sugar-containing polymer, 2-gluconamidoethyl methacrylamide (GAEMA), onto the surface of silica gel by atom transfer radical polymerization (ATRP). The SiO2-g-GAEMA with ATRP reaction time was characterized by Fourier infrared analysis, Thermogravimetric analysis (TGA), and elemental analysis. As the reaction time lengthened, the amount of GAEMA grafted on the surface of the silica gel gradually increased. The GAEMA is rich in amide bonds and hydroxyl groups and is a typical hydrophilic chromatography filler. Finally, SiO2-g-GAEMA (reaction time = 24 h) was chosen as the stationary phase of the chromatographic packing and evaluated with four polar compounds (uracil, cytosine, guanosine, and cytidine). Compared with unmodified silica gel, modified silica gel produces sharper peaks and better separation efficiency. This novel packing material may have a potential for application with highly isomerized sugar mixtures. View Full-Text
Keywords: glycopolymers; ATRP; SiO2-g-GAEMA; packing materials glycopolymers; ATRP; SiO2-g-GAEMA; packing materials
Show Figures

Graphical abstract

MDPI and ACS Style

Ma, G.; Luo, X.; Sun, X.; Wang, W.; Shou, Q.; Liang, X.; Liu, H. Glycopolymer Grafted Silica Gel as Chromatographic Packing Materials. Int. J. Mol. Sci. 2019, 20, 10.

AMA Style

Ma G, Luo X, Sun X, Wang W, Shou Q, Liang X, Liu H. Glycopolymer Grafted Silica Gel as Chromatographic Packing Materials. International Journal of Molecular Sciences. 2019; 20(1):10.

Chicago/Turabian Style

Ma, Gaoqi; Luo, Xitao; Sun, Xitong; Wang, Weiyan; Shou, Qinghui; Liang, Xiangfeng; Liu, Huizhou. 2019. "Glycopolymer Grafted Silica Gel as Chromatographic Packing Materials" Int. J. Mol. Sci. 20, no. 1: 10.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop