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Int. J. Mol. Sci. 2018, 19(9), 2749; https://doi.org/10.3390/ijms19092749

Whole Body Vibration Therapy after Ischemia Reduces Brain Damage in Reproductively Senescent Female Rats

1
Cerebral Vascular Disease Research Laboratories, Department of Neurology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA
2
Department of Neurology, University of Miami School of Medicine, Miami, FL 33136, USA
3
Department of Neurological Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA
4
Bruce W. Carter Department of Veterans Affairs Medical Center, Miami, FL 33125, USA
Current affiliation: Department or Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Ahmedabad (NIPER-A), Gandhinagar 382355, Gujarat, India
*
Authors to whom correspondence should be addressed.
Received: 23 August 2018 / Revised: 3 September 2018 / Accepted: 5 September 2018 / Published: 13 September 2018
(This article belongs to the Special Issue Molecular Pharmacology and Pathology of Strokes)
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Abstract

A risk of ischemic stroke increases exponentially after menopause. Even a mild-ischemic stroke can result in increased frailty. Frailty is a state of increased vulnerability to adverse outcomes, which subsequently increases risk of cerebrovascular events and severe cognitive decline, particularly after menopause. Several interventions to reduce frailty and subsequent risk of stroke and cognitive decline have been proposed in laboratory animals and patients. One of them is whole body vibration (WBV). WBV improves cerebral function and cognitive ability that deteriorates with increased frailty. The goal of the current study is to test the efficacy of WBV in reducing post-ischemic stroke frailty and brain damage in reproductively senescent female rats. Reproductively senescent Sprague-Dawley female rats were exposed to transient middle cerebral artery occlusion (tMCAO) and were randomly assigned to either WBV or no-WBV groups. Animals placed in the WBV group underwent 30 days of WBV (40 Hz) treatment performed twice daily for 15 min each session, 5 days each week. The motor functions of animals belonging to both groups were tested intermittently and at the end of the treatment period. Brains were then harvested for inflammatory markers and histopathological analysis. The results demonstrate a significant reduction in inflammatory markers and infarct volume with significant increases in brain-derived neurotrophic factor and improvement in functional activity after tMCAO in middle-aged female rats that were treated with WBV as compared to the no-WBV group. Our results may facilitate a faster translation of the WBV intervention for improved outcome after stroke, particularly among frail women. View Full-Text
Keywords: brain-derived neurotrophic factor; frailty; inflammasome proteins; interleukin-1β; peri-infarct area brain-derived neurotrophic factor; frailty; inflammasome proteins; interleukin-1β; peri-infarct area
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Raval, A.P.; Schatz, M.; Bhattacharya, P.; d’Adesky, N.; Rundek, T.; Dietrich, W.D.; Bramlett, H.M. Whole Body Vibration Therapy after Ischemia Reduces Brain Damage in Reproductively Senescent Female Rats. Int. J. Mol. Sci. 2018, 19, 2749.

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