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Open AccessArticle

The Beneficial Effect of Proanthocyanidins and Icariin on Biochemical Markers of Bone Turnover in Rats

1
Division of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10000 Zagreb, Croatia
2
Polyclinic Bagatin, Grada Vukovara 269a/10, 10000 Zagreb, Croatia
3
Department of Orthopaedic Surgery, Specialty Hospital St. Catherine, 49210 Zabok, Croatia
4
Croatian Veterinary Institute, Savska cesta 143, 10000 Zagreb, Croatia
5
Department of Gynaecology and Obstetrics, General Hospital Zabok, 49210 Zabok, Croatia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(9), 2746; https://doi.org/10.3390/ijms19092746
Received: 27 July 2018 / Revised: 10 September 2018 / Accepted: 10 September 2018 / Published: 13 September 2018
(This article belongs to the Special Issue Polyphenols: Nutrition, Physiology, Metabolism and Health Benefits)
Nutrition is an important factor that influences bone metabolism, the endocrine and/or paracrine system, and bone-active mineral elements homeostasis. We studied antiosteoporotic effects of grape seed proanthocyanidins extract, icariin or alendronate (ALN) in retinoic acid-induced (13cRA) bone loss in rats. Proanthocyanidins and icariin have beneficial effects on bone health; they have improved the bone weight reduction, the length and the diameter of the bone, calcium, and phosphorus content in bone ash, bone mineral density (BMD), the biochemical markers of bone turnover and uterus atrophy induced by 13cRA. All results suggest that proanthocyanidins and icariin reverse osteoporosis in 13cRA rats by stimulating bone formation or regulating bone resorption by their antioxidative and estrogenic-like activity without toxic side-effects observed in ALN treatment. View Full-Text
Keywords: proanthocyanidins; icariin; retinoic acid-induced bone loss; rats; bone markers proanthocyanidins; icariin; retinoic acid-induced bone loss; rats; bone markers
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MDPI and ACS Style

Oršolić, N.; Nemrava, J.; Jeleč, Ž.; Kukolj, M.; Odeh, D.; Terzić, S.; Fureš, R.; Bagatin, T.; Bagatin, D. The Beneficial Effect of Proanthocyanidins and Icariin on Biochemical Markers of Bone Turnover in Rats. Int. J. Mol. Sci. 2018, 19, 2746. https://doi.org/10.3390/ijms19092746

AMA Style

Oršolić N, Nemrava J, Jeleč Ž, Kukolj M, Odeh D, Terzić S, Fureš R, Bagatin T, Bagatin D. The Beneficial Effect of Proanthocyanidins and Icariin on Biochemical Markers of Bone Turnover in Rats. International Journal of Molecular Sciences. 2018; 19(9):2746. https://doi.org/10.3390/ijms19092746

Chicago/Turabian Style

Oršolić, Nada; Nemrava, Johann; Jeleč, Željko; Kukolj, Marina; Odeh, Dyana; Terzić, Svjetlana; Fureš, Rajko; Bagatin, Tomica; Bagatin, Dinko. 2018. "The Beneficial Effect of Proanthocyanidins and Icariin on Biochemical Markers of Bone Turnover in Rats" Int. J. Mol. Sci. 19, no. 9: 2746. https://doi.org/10.3390/ijms19092746

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