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Int. J. Mol. Sci. 2018, 19(9), 2619;

Papillomaviruses and Endocytic Trafficking

Tumour Virology Laboratory, International Centre for Genetic Engineering and Biotechnology, I-34149 Trieste, Italy
Department of Molecular Virology, Adam Mickiewicz University, Poznan 61–614, Poland
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 2 August 2018 / Revised: 24 August 2018 / Accepted: 29 August 2018 / Published: 4 September 2018
(This article belongs to the Special Issue Molecular Research on Cervical Cancer)
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Endocytic trafficking plays a major role in transport of incoming human papillomavirus (HPVs) from plasma membrane to the trans Golgi network (TGN) and ultimately into the nucleus. During this infectious entry, several cellular sorting factors are recruited by the viral capsid protein L2, which plays a critical role in ensuring successful transport of the L2/viral DNA complex to the nucleus. Later in the infection cycle, two viral oncoproteins, E5 and E6, have also been shown to modulate different aspects of endocytic transport pathways. In this review, we highlight how HPV makes use of and perturbs normal endocytic transport pathways, firstly to achieve infectious virus entry, secondly to produce productive infection and the completion of the viral life cycle and, finally, on rare occasions, to bring about the development of malignancy. View Full-Text
Keywords: HPV; viral capsid proteins; viral oncoproteins; endocytic machinery; retromer; retriever; sorting nexins HPV; viral capsid proteins; viral oncoproteins; endocytic machinery; retromer; retriever; sorting nexins

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Siddiqa, A.; Broniarczyk, J.; Banks, L. Papillomaviruses and Endocytic Trafficking. Int. J. Mol. Sci. 2018, 19, 2619.

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