Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets
Laboratory for Hereditary Cancer, Division of Molecular Medicine, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(9), 2562; https://doi.org/10.3390/ijms19092562
Received: 23 July 2018 / Revised: 17 August 2018 / Accepted: 25 August 2018 / Published: 29 August 2018
(This article belongs to the Special Issue Hedgehog Signaling)
GLI transcription factors have important roles in intracellular signaling cascade, acting as the main mediators of the HH-GLI signaling pathway. This is one of the major developmental pathways, regulated both canonically and non-canonically. Deregulation of the pathway during development leads to a number of developmental malformations, depending on the deregulated pathway component. The HH-GLI pathway is mostly inactive in the adult organism but retains its function in stem cells. Aberrant activation in adult cells leads to carcinogenesis through overactivation of several tightly regulated cellular processes such as proliferation, angiogenesis, EMT. Targeting GLI transcription factors has recently become a major focus of potential therapeutic protocols.
View Full-Text
Keywords:
HH-GLI signaling pathway; GLI transcription factors; signal transduction; malformations; cancer; therapy
▼
Show Figures
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Sabol, M.; Trnski, D.; Musani, V.; Ozretić, P.; Levanat, S. Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets. Int. J. Mol. Sci. 2018, 19, 2562. https://doi.org/10.3390/ijms19092562
AMA Style
Sabol M, Trnski D, Musani V, Ozretić P, Levanat S. Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets. International Journal of Molecular Sciences. 2018; 19(9):2562. https://doi.org/10.3390/ijms19092562
Chicago/Turabian StyleSabol, Maja; Trnski, Diana; Musani, Vesna; Ozretić, Petar; Levanat, Sonja. 2018. "Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets" Int. J. Mol. Sci. 19, no. 9: 2562. https://doi.org/10.3390/ijms19092562
Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
Search more from Scilit