N6-Methyladenosine Role in Acute Myeloid Leukaemia
Abstract
1. Introduction
2. m6A Writers, Erasers and Readers
3. m6A Effects on Gene Expression
4. m6A Roles in AML (Acute Myeloid Leukaemia) and Normal Haematopoiesis
4.1. WTAP (Wilms Tumor 1-Associated Protein) in AML
4.2. Core METTL3/METTL14 (Methyltransferase-Like Protein 3/Methyltransferase-Like Protein 14) Complex in AML
4.3. RBM15 (RNA-binding motif 15) in AML
4.4. FTO (Fat Mass and Obesity-Associated) in AML
4.5. Core METTL3/METTL14 Complex in Normal Haematopoiesis
5. Conclusions
Funding
Conflicts of Interest
Abbreviations
ABCF1 | ATP binding cassette subfamily F member 1 |
AML | Acute myeloid leukaemia |
CEBP | CCAAT enhancer binding protein |
CLIP | Cross-linked Immunoprecipitation |
ELAVL1 | ELAV like RNA binding protein 1 |
G3BP | G3BP stress granule assembly factor |
hnRNP | Heterogeneous nuclear ribonucleoprotein |
HSC | Haematopoietic stem cell |
HSPC | Haematopoietic stem and progenitor cells |
IGF2BP | Insulin-like growth factor 2 mRNA-binding protein |
KO | Knock-out |
LncRNA | Long non-coding RNA |
mESC | Mouse embryonic stem cells |
R-2HG | R-2-hydroxyglutarate |
SAM | S-adenosylmethionine |
UTR | Untranslated region |
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Protein | Classification | Function |
---|---|---|
METTL3 | Writer | Installs m6A in mRNA; promotes translation |
METTL14 | Writer | Cooperates with METTL3 in m6A installation |
METTL16 | Writer | Installs m6A in U6 snRNA and pre-mRNA |
FTO | Eraser | Remove m6A and m6Am from mRNA |
ALKBH5 | Eraser | Remove m6A from mRNA |
WTAP | Component of the regulatory MACOM complex | Regulates m6A installation |
VIRMA | Component of the regulatory MACOM complex | Regulates m6A installation |
CBLL1 | Component of the regulatory MACOM complex | Regulates m6A installation |
RBM15 | Component of the regulatory MACOM complex | Regulates m6A installation |
ZC3H13 | Component of the regulatory MACOM complex | Regulates m6A installation |
ABCF1 | Direct reader | Stimulates translation |
eIF3 | Direct reader | Stimulates translation |
HNRPA2B1 | Direct reader | Stimulates microRNA processing |
IGF2BPs | Direct readers | Increase mRNA stability |
YTHDC1 | Direct reader | Stimulates splicing and mRNA export |
YTHDC2 | Direct reader | Stimulates mRNA decay and translation |
YTHDF1 | Direct reader | Stimulates translation |
YTHDF2 | Direct reader | Stimulates mRNA decay |
YTHDF3 | Direct reader | Stimulates mRNA decay and translation |
FMR1 | Indirect reader | Inhibits translation |
HNRNPC | Indirect reader | Regulates splicing |
ELAVL1 | m6A repelled protein | Increases mRNA stability |
G3BPs | m6A repelled protein | Increase mRNA stability |
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Ianniello, Z.; Fatica, A. N6-Methyladenosine Role in Acute Myeloid Leukaemia. Int. J. Mol. Sci. 2018, 19, 2345. https://doi.org/10.3390/ijms19082345
Ianniello Z, Fatica A. N6-Methyladenosine Role in Acute Myeloid Leukaemia. International Journal of Molecular Sciences. 2018; 19(8):2345. https://doi.org/10.3390/ijms19082345
Chicago/Turabian StyleIanniello, Zaira, and Alessandro Fatica. 2018. "N6-Methyladenosine Role in Acute Myeloid Leukaemia" International Journal of Molecular Sciences 19, no. 8: 2345. https://doi.org/10.3390/ijms19082345
APA StyleIanniello, Z., & Fatica, A. (2018). N6-Methyladenosine Role in Acute Myeloid Leukaemia. International Journal of Molecular Sciences, 19(8), 2345. https://doi.org/10.3390/ijms19082345