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Int. J. Mol. Sci. 2018, 19(8), 2251; https://doi.org/10.3390/ijms19082251

The Perturbance of Microbiome and Gut-Brain Axis in Autism Spectrum Disorders

Department of Neurology, Rutgers New Jersey Medical School, 90 Bergen Street, DOC 8100, Newark, NJ 07103, USA
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Received: 3 July 2018 / Revised: 22 July 2018 / Accepted: 30 July 2018 / Published: 1 August 2018
(This article belongs to the Special Issue The (Microbiota)–Gut–Brain Axis: Hype or Revolution?)
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Abstract

Gastrointestinal problems have been documented in Autism Spectrum Disorder (ASD). Studies have found that these disturbances may be associated with an altered gut microbiome in ASD. Furthermore, in ASD, these alterations are implicated in increased gut permeability, or “leaky gut”, which allows bacterial metabolites to cross the gut barrier, impacting neurodevelopment during early childhood in susceptible subjects by way of gut-brain axis. In our review, we will discuss the interaction of gut microbiota and brain development in ASD and the signaling mechanisms underlying this interaction. We will also explore the potential for treatment of ASD by targeting the microbiome with probiotics. Finally, this paper will attempt to provide significance to the aggregation of the research in this area of research; providing our interpretations and assessments of future of this field. View Full-Text
Keywords: microbiome; dysbiosis; gastrointestinal disorders; autism spectrum disorders; gut brain axis; leaky gut syndrome microbiome; dysbiosis; gastrointestinal disorders; autism spectrum disorders; gut brain axis; leaky gut syndrome
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Fowlie, G.; Cohen, N.; Ming, X. The Perturbance of Microbiome and Gut-Brain Axis in Autism Spectrum Disorders. Int. J. Mol. Sci. 2018, 19, 2251.

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