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Int. J. Mol. Sci. 2018, 19(8), 2247;

β-Hydroxybutyrate Elicits Favorable Mitochondrial Changes in Skeletal Muscle

Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84604, USA
Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84604, USA
Author to whom correspondence should be addressed.
Received: 10 July 2018 / Revised: 26 July 2018 / Accepted: 27 July 2018 / Published: 1 August 2018
(This article belongs to the Special Issue The Effects of Ketones on Metabolic Function)
PDF [2192 KB, uploaded 1 August 2018]


The clinical benefit of ketosis has historically and almost exclusively centered on neurological conditions, lending insight into how ketones alter mitochondrial function in neurons. However, there is a gap in our understanding of how ketones influence mitochondria within skeletal muscle cells. The purpose of this study was to elucidate the specific effects of β-hydroxybutyrate (β-HB) on muscle cell mitochondrial physiology. In addition to increased cell viability, murine myotubes displayed beneficial mitochondrial changes evident in reduced H2O2 emission and less mitochondrial fission, which may be a result of a β-HB-induced reduction in ceramides. Furthermore, muscle from rats in sustained ketosis similarly produced less H2O2 despite an increase in mitochondrial respiration and no apparent change in mitochondrial quantity. In sum, these results indicate a general improvement in muscle cell mitochondrial function when β-HB is provided as a fuel. View Full-Text
Keywords: ketones; β-hydroxybutyrate; mitochondria; ceramides ketones; β-hydroxybutyrate; mitochondria; ceramides

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Parker, B.A.; Walton, C.M.; Carr, S.T.; Andrus, J.L.; Cheung, E.C.K.; Duplisea, M.J.; Wilson, E.K.; Draney, C.; Lathen, D.R.; Kenner, K.B.; Thomson, D.M.; Tessem, J.S.; Bikman, B.T. β-Hydroxybutyrate Elicits Favorable Mitochondrial Changes in Skeletal Muscle. Int. J. Mol. Sci. 2018, 19, 2247.

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