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Regulation of Energy Metabolism during Early B Lymphocyte Development

1
Division of Molecular Immunology, Nikolaus-Fiebiger-Center, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany
2
Institute of Comparative Molecular Endocrinology (CME), University of Ulm, 89081 Ulm, Germany
3
Department of Internal Medicine V, University Hospital, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(8), 2192; https://doi.org/10.3390/ijms19082192
Received: 16 July 2018 / Accepted: 25 July 2018 / Published: 27 July 2018
The most important feature of humoral immunity is the adaptation of the diversity of newly generated B cell receptors, that is, the antigen receptor repertoire, to the body’s own and foreign structures. This includes the transient propagation of B progenitor cells and B cells, which possess receptors that are positively selected via anabolic signalling pathways under highly competitive conditions. The metabolic regulation of early B-cell development thus has important consequences for the expansion of normal or malignant pre-B cell clones. In addition, cellular senescence programs based on the expression of B cell identity factors, such as Pax5, act to prevent excessive proliferation and cellular deviation. Here, we review the basic mechanisms underlying the regulation of glycolysis and oxidative phosphorylation during early B cell development in bone marrow. We focus on the regulation of glycolysis and mitochondrial oxidative phosphorylation at the transition from non-transformed pro- to pre-B cells and discuss some ongoing issues. We introduce Swiprosin-2/EFhd1 as a potential regulator of glycolysis in pro-B cells that has also been linked to Ca2+-mediated mitoflashes. Mitoflashes are bioenergetic mitochondrial events that control mitochondrial metabolism and signalling in both healthy and disease states. We discuss how Ca2+ fluctuations in pro- and pre-B cells may translate into mitoflashes in early B cells and speculate about the consequences of these changes. View Full-Text
Keywords: B lymphocyte development; metabolism; EFhd1; pre-BCR; mitochondria; mitoflash; oxidative phosphorylation; glycolysis B lymphocyte development; metabolism; EFhd1; pre-BCR; mitochondria; mitoflash; oxidative phosphorylation; glycolysis
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Urbanczyk, S.; Stein, M.; Schuh, W.; Jäck, H.-M.; Mougiakakos, D.; Mielenz, D. Regulation of Energy Metabolism during Early B Lymphocyte Development. Int. J. Mol. Sci. 2018, 19, 2192.

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