Role of Membrane Cholesterol Levels in Activation of Lyn upon Cell Detachment
AbstractCholesterol, a major component of the plasma membrane, determines the physical
properties of biological membranes and plays a critical role in the assembly of membrane
microdomains. Enrichment or deprivation of membrane cholesterol affects the activities of many
signaling molecules at the plasma membrane. Cell detachment changes the structure of the plasma
membrane and influences the localizations of lipids, including cholesterol. Recent studies showed
that cell detachment changes the activities of a variety of signaling molecules. We previously reported
that the localization and the function of the Src-family kinase Lyn are critically regulated by its
membrane anchorage through lipid modifications. More recently, we found that the localization and
the activity of Lyn were changed upon cell detachment, although the manners of which vary between
cell types. In this review, we highlight the changes in the localization of Lyn and a role of cholesterol
in the regulation of Lyn’s activation following cell detachment.
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Morinaga, T.; Yamaguchi, N.; Nakayama, Y.; Tagawa, M.; Yamaguchi, N. Role of Membrane Cholesterol Levels in Activation of Lyn upon Cell Detachment. Int. J. Mol. Sci. 2018, 19, 1811.
Morinaga T, Yamaguchi N, Nakayama Y, Tagawa M, Yamaguchi N. Role of Membrane Cholesterol Levels in Activation of Lyn upon Cell Detachment. International Journal of Molecular Sciences. 2018; 19(6):1811.Chicago/Turabian Style
Morinaga, Takao; Yamaguchi, Noritaka; Nakayama, Yuji; Tagawa, Masatoshi; Yamaguchi, Naoto. 2018. "Role of Membrane Cholesterol Levels in Activation of Lyn upon Cell Detachment." Int. J. Mol. Sci. 19, no. 6: 1811.
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