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Role of Membrane Cholesterol Levels in Activation of Lyn upon Cell Detachment

1
Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan
2
Laboratory of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan
3
Department of Biochemistry and Molecular Biology, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan
4
Department of Molecular Biology and Oncology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(6), 1811; https://doi.org/10.3390/ijms19061811
Received: 28 May 2018 / Revised: 14 June 2018 / Accepted: 15 June 2018 / Published: 19 June 2018
(This article belongs to the Special Issue Cholesterol and Lipoprotein Metabolism)
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PDF [1557 KB, uploaded 19 June 2018]
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Abstract

Cholesterol, a major component of the plasma membrane, determines the physical
properties of biological membranes and plays a critical role in the assembly of membrane
microdomains. Enrichment or deprivation of membrane cholesterol affects the activities of many
signaling molecules at the plasma membrane. Cell detachment changes the structure of the plasma
membrane and influences the localizations of lipids, including cholesterol. Recent studies showed
that cell detachment changes the activities of a variety of signaling molecules. We previously reported
that the localization and the function of the Src-family kinase Lyn are critically regulated by its
membrane anchorage through lipid modifications. More recently, we found that the localization and
the activity of Lyn were changed upon cell detachment, although the manners of which vary between
cell types. In this review, we highlight the changes in the localization of Lyn and a role of cholesterol
in the regulation of Lyn’s activation following cell detachment.

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Keywords: cholesterol; Src-family kinases; subcellular localization; membrane distribution; Lyn activation; cell–scaffold interactions; cell detachment cholesterol; Src-family kinases; subcellular localization; membrane distribution; Lyn activation; cell–scaffold interactions; cell detachment
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Morinaga, T.; Yamaguchi, N.; Nakayama, Y.; Tagawa, M.; Yamaguchi, N. Role of Membrane Cholesterol Levels in Activation of Lyn upon Cell Detachment. Int. J. Mol. Sci. 2018, 19, 1811.

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