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Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety

REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, nº 228, 4050-313 Porto, Portugal
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Int. J. Mol. Sci. 2018, 19(6), 1668; https://doi.org/10.3390/ijms19061668
Received: 19 April 2018 / Revised: 23 May 2018 / Accepted: 23 May 2018 / Published: 5 June 2018
(This article belongs to the Special Issue Natural and Semi-Synthetic Small Molecules in Drug Discovery)
Pyrrolizidine alkaloids (PA) are widely distributed in plants throughout the world, frequently in species relevant for human consumption. Apart from the toxicity that these molecules can cause in humans and livestock, PA are also known for their wide range of pharmacological properties, which can be exploited in drug discovery programs. In this work we review the current body of knowledge regarding the chemistry, toxicology, pharmacology and food safety of PA. View Full-Text
Keywords: pyrrolizidine alkaloids; chemistry; toxicity; pharmacological properties; food safety pyrrolizidine alkaloids; chemistry; toxicity; pharmacological properties; food safety
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MDPI and ACS Style

Moreira, R.; Pereira, D.M.; Valentão, P.; Andrade, P.B. Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety. Int. J. Mol. Sci. 2018, 19, 1668. https://doi.org/10.3390/ijms19061668

AMA Style

Moreira R, Pereira DM, Valentão P, Andrade PB. Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety. International Journal of Molecular Sciences. 2018; 19(6):1668. https://doi.org/10.3390/ijms19061668

Chicago/Turabian Style

Moreira, Rute, David M. Pereira, Patrícia Valentão, and Paula B. Andrade. 2018. "Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety" International Journal of Molecular Sciences 19, no. 6: 1668. https://doi.org/10.3390/ijms19061668

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