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Recognizing Depression from the Microbiota–Gut–Brain Axis

by Shan Liang 1, Xiaoli Wu 1,2, Xu Hu 1, Tao Wang 1 and Feng Jin 1,*
1
Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
2
Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(6), 1592; https://doi.org/10.3390/ijms19061592
Received: 28 March 2018 / Revised: 19 April 2018 / Accepted: 2 May 2018 / Published: 29 May 2018
(This article belongs to the Special Issue The (Microbiota)–Gut–Brain Axis: Hype or Revolution?)
Major depression is one of the leading causes of disability, morbidity, and mortality worldwide. The brain–gut axis functions are disturbed, revealed by a dysfunction of the brain, immune system, endocrine system, and gut. Traditional depression treatments all target the brain, with different drugs and/or psychotherapy. Unfortunately, most of the patients have never received any treatment. Studies indicate that gut microbiota could be a direct cause for the disorder. Abnormal microbiota and the microbiota–gut–brain dysfunction may cause mental disorders, while correcting these disturbance could alleviate depression. Nowadays, the gut microbiota modulation has become a hot topic in treatment research of mental disorders. Depression is closely related with the health condition of the brain–gut axis, and maintaining/restoring the normal condition of gut microbiota helps in the prevention/therapy of mental disorders. View Full-Text
Keywords: major depressive disorder; brain–gut axis; microbiota–gut–brain axis; gut microbiota; psychobiotics major depressive disorder; brain–gut axis; microbiota–gut–brain axis; gut microbiota; psychobiotics
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Liang, S.; Wu, X.; Hu, X.; Wang, T.; Jin, F. Recognizing Depression from the Microbiota–Gut–Brain Axis. Int. J. Mol. Sci. 2018, 19, 1592.

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