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Article

Polymeric Micelles Based on Modified Glycol Chitosan for Paclitaxel Delivery: Preparation, Characterization and Evaluation

by
Na Liang
1,
Shaoping Sun
2,*,
Xianfeng Gong
2,
Qiang Li
2,
Pengfei Yan
2,3,* and
Fude Cui
4
1
Key Laboratory of Photochemical Biomaterials and Energy Storage Materials, Heilongjiang Province, College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China
2
Key Laboratory of Chemical Engineering Process & Technology for High-Efficiency Conversion, College of Heilongjiang Province; School of Chemistry and Material Science, Heilongjiang University, Harbin 150080, China
3
Key Laboratory of Functional Inorganic Material Chemistry, Heilongjiang University, Harbin 150080, China
4
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(6), 1550; https://doi.org/10.3390/ijms19061550
Submission received: 22 April 2018 / Revised: 15 May 2018 / Accepted: 15 May 2018 / Published: 23 May 2018
(This article belongs to the Special Issue Synthesis and Applications of Biopolymer Composites)
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Abstract

Amphiphilic polymer of α-tocopherol succinate modified glycol chitosan (TS-GC) was successfully constructed by conjugating α-tocopherol succinate to the skeleton of glycol chitosan and characterized by Fourier-transform infrared (FT-IR) and proton nuclear magnetic resonance (1H-NMR). In aqueous milieu, the conjugates self-assembled to micelles with the critical aggregation concentration of 7.2 × 10−3 mg/mL. Transmission electron microscope (TEM) observation and dynamic light scattering (DLS) measurements were carried out to determine the physicochemical properties of the micelles. The results revealed that paclitaxel (PTX)-loaded TS-GC micelles were spherical in shape. Moreover, the PTX-loaded micelles showed increased particle sizes (35 nm vs. 142 nm) and a little reduced zeta potential (+19 mV vs. +16 mV) compared with blank micelles. The X-ray diffraction (XRD) spectra demonstrated that PTX existed inside the micelles in amorphous or molecular state. In vitro and in vivo tests showed that the PTX-loaded TS-GC micelles had advantages over the Cremophor EL-based formulation in terms of low toxicity level and increased dose, which suggested the potential of the polymer as carriers for PTX to improve their delivery properties.
Keywords: glycol chitosan; α-tocopherol succinate; amphiphilic polymer; micelles; paclitaxel glycol chitosan; α-tocopherol succinate; amphiphilic polymer; micelles; paclitaxel

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MDPI and ACS Style

Liang, N.; Sun, S.; Gong, X.; Li, Q.; Yan, P.; Cui, F. Polymeric Micelles Based on Modified Glycol Chitosan for Paclitaxel Delivery: Preparation, Characterization and Evaluation. Int. J. Mol. Sci. 2018, 19, 1550. https://doi.org/10.3390/ijms19061550

AMA Style

Liang N, Sun S, Gong X, Li Q, Yan P, Cui F. Polymeric Micelles Based on Modified Glycol Chitosan for Paclitaxel Delivery: Preparation, Characterization and Evaluation. International Journal of Molecular Sciences. 2018; 19(6):1550. https://doi.org/10.3390/ijms19061550

Chicago/Turabian Style

Liang, Na, Shaoping Sun, Xianfeng Gong, Qiang Li, Pengfei Yan, and Fude Cui. 2018. "Polymeric Micelles Based on Modified Glycol Chitosan for Paclitaxel Delivery: Preparation, Characterization and Evaluation" International Journal of Molecular Sciences 19, no. 6: 1550. https://doi.org/10.3390/ijms19061550

APA Style

Liang, N., Sun, S., Gong, X., Li, Q., Yan, P., & Cui, F. (2018). Polymeric Micelles Based on Modified Glycol Chitosan for Paclitaxel Delivery: Preparation, Characterization and Evaluation. International Journal of Molecular Sciences, 19(6), 1550. https://doi.org/10.3390/ijms19061550

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