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Insulin-Like Growth Factor (IGF) System in Liver Diseases
Open AccessArticle

Somatotropic Axis Dysfunction in Non-Alcoholic Fatty Liver Disease: Beneficial Hepatic and Systemic Effects of Hormone Supplementation

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Departament of Gastroenterology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago 8320000, Chile
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Faculty of Biological Sciences, Universidad Andrés Bello, Santiago 8320000, Chile
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Departament of Pathotology, Clínica Las Condes, Santiago 8320000, Chile
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Department of Pathology, Hospital Clínico Universidad de Chile, Santiago 8320000, Chile
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Department of Pathology, Hospital Clínico San Juan de Dios, Santiago 8320000, Chile
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Faculty of Arts, Pontificia Universidad Católica de Chile, Santiago 8320000, Chile
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Department of Health Sciences, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8320000, Chile
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Centro de Envejecimiento y Regeneración (CARE), Pontificia Universidad Católica de Chile, Santiago 8320000, Chile
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2018, 19(5), 1339; https://doi.org/10.3390/ijms19051339
Received: 28 February 2018 / Revised: 30 March 2018 / Accepted: 10 April 2018 / Published: 2 May 2018
(This article belongs to the Special Issue IGFs in Health and Disease)
Background: Somatotropic axis dysfunction associated with non-alcoholic fatty liver disease (NAFLD) has potential multisystemic detrimental effects. Here, we analysed the effects of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) supplementation on liver histology, adipokine profile and muscle function in an NAFLD model. Methods: C57BL/6 mice were fed with a high fat diet (HFD) for 12 weeks and were separated into three groups treated for 4 weeks with: (1) High fat diet (HFD) (n = 10); (2) HFD + GH 9 μg/g/d (n = 10); (3) HFD + IGF-1 0.02 µg/g/d (n = 9). A control group fed a chow diet was included (n = 6). Liver histology, liver triglycerides content, serum alanine aminotransferase (ALT) activity, adiponectin and leptin serum levels, in vivo muscle strength, tetanic force and muscle fibre cross-sectional area (CSA) were measured. Results: HFD + GH and HFD + IGF-1 groups showed significantly lower ALT activity compared to HFD (p < 0.01). Liver triglyceride content in HFD + GH was decreased compared to HFD (p < 0.01). Histologic steatosis score was increased in HFD and HFD + GH group (p < 0.01), whereas HFD + IGF-1 presented no difference compared to the chow group (p = 0.3). HFD + GH group presented lower serum leptin and adiponectin levels compared to HFD. GH and IGF-1 supplementation therapy reverted HFD-induced reduction in muscle strength and CSA (sarcopenia). Conclusions: GH and IGF-1 supplementation induced significant improvement in liver steatosis, aminotransferases and sarcopenia in a diet-induced NAFLD model. View Full-Text
Keywords: fatty liver; somatotropic axis; growth hormone; insulin growth factor 1; IGF-1 fatty liver; somatotropic axis; growth hormone; insulin growth factor 1; IGF-1
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Cabrera, D.; Cabello-Verrugio, C.; Solís, N.; San Martín, D.; Cofré, C.; Pizarro, M.; Arab, J.P.; Abrigo, J.; Campos, F.; Irigoyen, B.; Carrasco-Avino, G.; Bezares, K.; Riquelme, V.; Riquelme, A.; Arrese, M.; Barrera, F. Somatotropic Axis Dysfunction in Non-Alcoholic Fatty Liver Disease: Beneficial Hepatic and Systemic Effects of Hormone Supplementation. Int. J. Mol. Sci. 2018, 19, 1339.

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