Next Article in Journal
Metal Free Graphene Oxide (GO) Nanosheets and Pristine-Single Wall Carbon Nanotubes (p-SWCNTs) Biocompatibility Investigation: A Comparative Study in Different Human Cell Lines
Next Article in Special Issue
Dynamic DNA Methylation in Plant Growth and Development
Previous Article in Journal
Novel Ex Vivo Human Osteochondral Explant Model of Knee and Spine Osteoarthritis Enables Assessment of Inflammatory and Drug Treatment Responses
Previous Article in Special Issue
Memory Function in Feeding Habit Transformation of Mandarin Fish (Siniperca chuatsi)
Open AccessReview

DNA Methyltransferases, DNA Methylation, and Age-Associated Cognitive Function

by Di Cui 1 and Xiangru Xu 1,2,*
Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany
Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06520, USA
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(5), 1315;
Received: 11 April 2018 / Revised: 20 April 2018 / Accepted: 20 April 2018 / Published: 28 April 2018
(This article belongs to the Special Issue DNA Methylation)
Ageing, a leading cause of the decline/deficits in human learning, memory, and cognitive abilities, is a major risk factor for age-associated neurodegenerative disorders such as Alzheimer’s disease. Emerging evidence suggests that epigenetics, an inheritable but reversible biochemical process, plays a crucial role in the pathogenesis of age-related neurological disorders. DNA methylation, the best-known epigenetic mark, has attracted most attention in this regard. DNA methyltransferases (DNMTs) are key enzymes in mediating the DNA methylation process, by which a methyl group is transferred, faithfully or anew, to genomic DNA sequences. Biologically, DNMTs are important for gene imprinting. Accumulating evidence suggests that DNMTs not only play critical roles, including gene imprinting and transcription regulation, in early development stages of the central nervous system (CNS), but also are indispensable in adult learning, memory, and cognition. Therefore, the impact of DNMTs and DNA methylation on age-associated cognitive functions and neurodegenerative diseases has emerged as a pivotal topic in the field. In this review, the effects of each DNMT on CNS development and healthy and pathological ageing are discussed. View Full-Text
Keywords: DNMTs; DNA methylation; synaptic gene expression, CNS; cognitive ageing DNMTs; DNA methylation; synaptic gene expression, CNS; cognitive ageing
Show Figures

Figure 1

MDPI and ACS Style

Cui, D.; Xu, X. DNA Methyltransferases, DNA Methylation, and Age-Associated Cognitive Function. Int. J. Mol. Sci. 2018, 19, 1315.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop