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Role of Inflammation in Diabetic Retinopathy

Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48105, USA
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(4), 942;
Received: 15 February 2018 / Revised: 9 March 2018 / Accepted: 17 March 2018 / Published: 22 March 2018
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Diabetic retinopathy is a common complication of diabetes and remains the leading cause of blindness among the working-age population. For decades, diabetic retinopathy was considered only a microvascular complication, but the retinal microvasculature is intimately associated with and governed by neurons and glia, which are affected even prior to clinically detectable vascular lesions. While progress has been made to improve the vascular alterations, there is still no treatment to counteract the early neuro-glial perturbations in diabetic retinopathy. Diabetes is a complex metabolic disorder, characterized by chronic hyperglycemia along with dyslipidemia, hypoinsulinemia and hypertension. Increasing evidence points to inflammation as one key player in diabetes-associated retinal perturbations, however, the exact underlying molecular mechanisms are not yet fully understood. Interlinked molecular pathways, such as oxidative stress, formation of advanced glycation end-products and increased expression of vascular endothelial growth factor have received a lot of attention as they all contribute to the inflammatory response. In the current review, we focus on the involvement of inflammation in the pathophysiology of diabetic retinopathy with special emphasis on the functional relationships between glial cells and neurons. Finally, we summarize recent advances using novel targets to inhibit inflammation in diabetic retinopathy. View Full-Text
Keywords: diabetic retinopathy; neuroprotection; inflammation; neurodegeneration; pathophysiology; microglia; astrocytes; Müller glial cells; crystallins diabetic retinopathy; neuroprotection; inflammation; neurodegeneration; pathophysiology; microglia; astrocytes; Müller glial cells; crystallins

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Rübsam, A.; Parikh, S.; Fort, P.E. Role of Inflammation in Diabetic Retinopathy. Int. J. Mol. Sci. 2018, 19, 942.

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