Next Article in Journal
Detrimental Effects of Helium Ion Irradiation on Cognitive Performance and Cortical Levels of MAP-2 in B6D2F1 Mice
Next Article in Special Issue
Decellularized Diaphragmatic Muscle Drives a Constructive Angiogenic Response In Vivo
Previous Article in Journal
NF-κB-Mediated Inflammation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage. Does Autophagy Play a Role?
Previous Article in Special Issue
Microfabrication-Based Three-Dimensional (3-D) Extracellular Matrix Microenvironments for Cancer and Other Diseases
Open AccessReview

Human Cancer and Platelet Interaction, a Potential Therapeutic Target

1, 2 and 1,3,*
Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA
Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, University of Kentucky, 741 South Limestone Street, Lexington, KY 40536, USA
Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, KY 40536, USA
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(4), 1246;
Received: 2 March 2018 / Revised: 30 March 2018 / Accepted: 16 April 2018 / Published: 20 April 2018
(This article belongs to the Special Issue Extracellular Matrix in Development and Disease)
PDF [615 KB, uploaded 3 May 2018]


Cancer patients experience a four-fold increase in thrombosis risk, indicating that cancer development and progression are associated with platelet activation. Xenograft experiments and transgenic mouse models further demonstrate that platelet activation and platelet-cancer cell interaction are crucial for cancer metastasis. Direct or indirect interaction of platelets induces cancer cell plasticity and enhances survival and extravasation of circulating cancer cells during dissemination. In vivo and in vitro experiments also demonstrate that cancer cells induce platelet aggregation, suggesting that platelet-cancer interaction is bidirectional. Therefore, understanding how platelets crosstalk with cancer cells may identify potential strategies to inhibit cancer metastasis and to reduce cancer-related thrombosis. Here, we discuss the potential function of platelets in regulating cancer progression and summarize the factors and signaling pathways that mediate the cancer cell-platelet interaction. View Full-Text
Keywords: cancer metastasis; platelet; biomarker; cancer therapy cancer metastasis; platelet; biomarker; cancer therapy

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Printed Edition Available!
A printed edition of this Special Issue is available here.

Share & Cite This Article

MDPI and ACS Style

Wang, S.; Li, Z.; Xu, R. Human Cancer and Platelet Interaction, a Potential Therapeutic Target. Int. J. Mol. Sci. 2018, 19, 1246.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top