The Role, Involvement and Function(s) of Interleukin-35 and Interleukin-37 in Disease Pathogenesis
AbstractThe recently identified cytokines—interleukin (IL)-35 and interleukin (IL)-37—have been described for their anti-inflammatory and immune-modulating actions in numerous inflammatory diseases, auto-immune disorders, malignancies, infectious diseases and sepsis. Either cytokine has been reported to be reduced and in some cases elevated and consequently contributed towards disease pathogenesis. In view of the recent advances in utilizing cytokine profiles for the development of biological macromolecules, beneficial in the management of certain intractable immune-mediated disorders, these recently characterized cytokines (IL-35 and IL-37) offer potential as reasonable targets for the discovery of novel immune-modulating anti-inflammatory therapies. A detailed comprehension of their sophisticated regulatory mechanisms and patterns of expression may provide unique opportunities for clinical application as highly selective and target specific therapeutic agents. This review seeks to summarize the recent advancements in discerning the dynamics, mechanisms, immunoregulatory and anti-inflammatory actions of IL-35 and IL-37 as they relate to disease pathogenesis. View Full-Text
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Bello, R.O.; Chin, V.K.; Abd Rachman Isnadi, M.F.; Abd Majid, R.; Atmadini Abdullah, M.; Lee, T.Y.; Amiruddin Zakaria, Z.; Hussain, M.K.; Basir, R. The Role, Involvement and Function(s) of Interleukin-35 and Interleukin-37 in Disease Pathogenesis. Int. J. Mol. Sci. 2018, 19, 1149.
Bello RO, Chin VK, Abd Rachman Isnadi MF, Abd Majid R, Atmadini Abdullah M, Lee TY, Amiruddin Zakaria Z, Hussain MK, Basir R. The Role, Involvement and Function(s) of Interleukin-35 and Interleukin-37 in Disease Pathogenesis. International Journal of Molecular Sciences. 2018; 19(4):1149.Chicago/Turabian Style
Bello, Ramatu O.; Chin, Voon K.; Abd Rachman Isnadi, Mohammad F.; Abd Majid, Roslaini; Atmadini Abdullah, Maizaton; Lee, Tze Y.; Amiruddin Zakaria, Zainul; Hussain, Mohd K.; Basir, Rusliza. 2018. "The Role, Involvement and Function(s) of Interleukin-35 and Interleukin-37 in Disease Pathogenesis." Int. J. Mol. Sci. 19, no. 4: 1149.
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