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Int. J. Mol. Sci. 2018, 19(4), 1124;

Comparative Genomics and Transcriptome Profiling in Primary Aldosteronism

Medizinische Klinik und Poliklinik IV, Klinikum der Universität, Ludwig-Maximilians-Universität München, 80336 Munich, Germany
Division of Pathology, Department of Medical Sciences, University of Torino, 10124 Torino, Italy
Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Torino, 10126 Torino, Italy
Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, UniversitätsSpital Zürich, CH-8091 Zurich, Switzerland
Author to whom correspondence should be addressed.
Received: 15 February 2018 / Revised: 4 April 2018 / Accepted: 6 April 2018 / Published: 9 April 2018
(This article belongs to the Special Issue Role of Genomics in the Management of Hypertension)
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Primary aldosteronism is the most common form of endocrine hypertension with a prevalence of 6% in the general population with hypertension. The genetic basis of the four familial forms of primary aldosteronism (familial hyperaldosteronism FH types I–IV) and the majority of sporadic unilateral aldosterone-producing adenomas has now been resolved. Familial forms of hyperaldosteronism are, however, rare. The sporadic forms of the disease prevail and these are usually caused by either a unilateral aldosterone-producing adenoma or bilateral adrenal hyperplasia. Aldosterone-producing adenomas frequently carry a causative somatic mutation in either of a number of genes with the KCNJ5 gene, encoding an inwardly rectifying potassium channel, a recurrent target harboring mutations at a prevalence of more than 40% worldwide. Other than genetic variations, gene expression profiling of aldosterone-producing adenomas has shed light on the genes and intracellular signalling pathways that may play a role in the pathogenesis and pathophysiology of these tumors. View Full-Text
Keywords: primary aldosteronism; aldosterone; aldosterone-producing adenoma; transcriptome profiing primary aldosteronism; aldosterone; aldosterone-producing adenoma; transcriptome profiing

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Aristizabal Prada, E.T.; Castellano, I.; Sušnik, E.; Yang, Y.; Meyer, L.S.; Tetti, M.; Beuschlein, F.; Reincke, M.; Williams, T.A. Comparative Genomics and Transcriptome Profiling in Primary Aldosteronism. Int. J. Mol. Sci. 2018, 19, 1124.

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